ArticlePloS one2016
Top-Down Network Effective Connectivity in Abstinent Substance Dependent Individuals.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- The subcortical brain regions influence the cortical areas during resting-state: an fMRI study.Frontiers in human neuroscience · 2024Article
- White matter-based brain network topological properties associated with individual impulsivity.Scientific reports · 2023Article
- A Systematic Review of Pharmacological Treatments for Internet Gaming Disorder.Psychiatry investigation · 2023Article
- Anomalies in global network connectivity associated with early recovery from alcohol dependence: A network transcranial magnetic stimulation and electroencephalography study.Addiction biology · 2022Article
- Alterations of local functional connectivity in lifespan: A resting-state fMRI study.Brain and behavior · 2020Article
- Brain networks underlying vulnerability and resilience to drug addiction.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Neuroimaging reward, craving, learning, and cognitive control in substance use disorders: review and implications for treatment.The British journal of radiology · 2019Review
- Increasing robustness of pairwise methods for effective connectivity in magnetic resonance imaging by using fractional moment series of BOLD signal distributions.Network neuroscience (Cambridge, Mass.) · 2019Article
- Disentangling causal webs in the brain using functional magnetic resonance imaging: A review of current approaches.Network neuroscience (Cambridge, Mass.) · 2019Review
- Bupropion Shows Different Effects on Brain Functional Connectivity in Patients With Internet-Based Gambling Disorder and Internet Gaming Disorder.Frontiers in psychiatry · 2018Article
- Comparing the Effects of Bupropion and Escitalopram on Excessive Internet Game Play in Patients with Major Depressive Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2017Article
- The impact of hemodynamic variability and signal mixing on the identifiability of effective connectivity structures in BOLD fMRI.Brain and behavior · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveWe hypothesized that compared to healthy controls, long-term abstinent substance dependent individuals (SDI) will differ in their effective connectivity between large-scale brain networks and demonstrate increased directional information from executive control to interoception-, reward-, and habit-related networks. In addition, using graph theory to compare network efficiencies we predicted decreased small-worldness in SDI compared to controls.
methods50 SDI and 50 controls of similar sex and age completed psychological surveys and resting state fMRI. fMRI results were analyzed using group independent component analysis; 14 networks-of-interest (NOI) were selected using template matching to a canonical set of resting state networks. The number, direction, and strength of connections between NOI were analyzed with Granger Causality. Within-group thresholds were p<0.005 using a bootstrap permutation. Between group thresholds were p<0.05, FDR-corrected for multiple comparisons. NOI were correlated with behavioral measures, and group-level graph theory measures were compared.
resultsCompared to controls, SDI showed significantly greater Granger causal connectivity from right executive control network (RECN) to dorsal default mode network (dDMN) and from dDMN to basal ganglia network (BGN). RECN was negatively correlated with impulsivity, behavioral approach, and negative affect; dDMN was positively correlated with impulsivity. Among the 14 NOI, SDI showed greater bidirectional connectivity; controls showed more unidirectional connectivity. SDI demonstrated greater global efficiency and lower local efficiency.
conclusionsIncreased effective connectivity in long-term abstinent drug users may reflect improved cognitive control over habit and reward processes. Higher global and lower local efficiency across all networks in SDI compared to controls may reflect connectivity changes associated with drug dependence or remission and requires future, longitudinal studies to confirm.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.