ArticlePLoS biology2016
Relative Contributions of Specific Activity Histories and Spontaneous Processes to Size Remodeling of Glutamatergic Synapses.
Article in PLoS biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
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- Long-Term Potentiation Produces a Sustained Expansion of Synaptic Information Storage Capacity in Adult Rat Hippocampus.bioRxiv : the preprint server for biology · 2024Article
- A stable sensory map emerges from a dynamic equilibrium of neurons with unstable tuning properties.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Microfluidic Bi-Layer Platform to Study Functional Interaction between Co-Cultured Neural Networks with Unidirectional Synaptic Connectivity.Micromachines · 2023Article
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- Drifting assemblies for persistent memory: Neuron transitions and unsupervised compensation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer's Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2021Review
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- Spine dynamics in the brain, mental disorders and artificial neural networks.Nature reviews. Neuroscience · 2021Review
- Reproducing asymmetrical spine shape fluctuations in a model of actin dynamics predicts self-organized criticality.Scientific reports · 2021Article
- Proline-rich transmembrane protein 2 (PRRT2) regulates the actin cytoskeleton during synaptogenesis.Cell death & disease · 2020Article
- Activity Dependent and Independent Determinants of Synaptic Size Diversity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Emergence of Stable Synaptic Clusters on Dendrites Through Synaptic Rewiring.Frontiers in computational neuroscience · 2020Article
- Modeling the Shape of Synaptic Spines by Their Actin Dynamics.Frontiers in synaptic neuroscience · 2020Article
- A non-fluorescent HaloTag blocker for improved measurement and visualization of protein synthesis in living cells.F1000Research · 2020Article
- Stable memory with unstable synapses.Nature communications · 2019Article
- Differential role of pre- and postsynaptic neurons in the activity-dependent control of synaptic strengths across dendrites.PLoS biology · 2019Article
- Self-organized reactivation maintains and reinforces memories despite synaptic turnover.eLife · 2019Article
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- Structural Plasticity on the SpiNNaker Many-Core Neuromorphic System.Frontiers in neuroscience · 2018Article
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2 authors.
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Abstract
The idea that synaptic properties are defined by specific pre- and postsynaptic activity histories is one of the oldest and most influential tenets of contemporary neuroscience. Recent studies also indicate, however, that synaptic properties often change spontaneously, even in the absence of specific activity patterns or any activity whatsoever. What, then, are the relative contributions of activity history-dependent and activity history-independent processes to changes synapses undergo? To compare the relative contributions of these processes, we imaged, in spontaneously active networks of cortical neurons, glutamatergic synapses formed between the same axons and neurons or dendrites under the assumption that their similar activity histories should result in similar size changes over timescales of days. The size covariance of such commonly innervated (CI) synapses was then compared to that of synapses formed by different axons (non-CI synapses) that differed in their activity histories. We found that the size covariance of CI synapses was greater than that of non-CI synapses; yet overall size covariance of CI synapses was rather modest. Moreover, momentary and time-averaged sizes of CI synapses correlated rather poorly, in perfect agreement with published electron microscopy-based measurements of mouse cortex synapses. A conservative estimate suggested that ~40% of the observed size remodeling was attributable to specific activity histories, whereas ~10% and ~50% were attributable to cell-wide and spontaneous, synapse-autonomous processes, respectively. These findings demonstrate that histories of naturally occurring activity patterns can direct glutamatergic synapse remodeling but also suggest that the contributions of spontaneous, possibly stochastic, processes are at least as great.
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