ArticleNature genetics2016
Deregulation of DUX4 and ERG in acute lymphoblastic leukemia.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00137111 (Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia), which is not on this map. Cited by 202 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed, 2 pooled it
25.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia
Who cites it
202 citing papers in PubMed, 2 syntheses or guidelines pooled it, 316 citations in OpenAlex.
- Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk.Nature communications · 2019Pooled it
- Initial Diagnostic Work-Up of Acute Leukemia: ASCO Clinical Practice Guideline Endorsement of the College of American Pathologists and American Society of Hematology Guideline.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2019Guideline
- Trial
- Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures.Scientific reports · 2019Trial
- Clinical and molecular characteristics ofHaematologica · 2019Trial
- Trial
- Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group.Blood · 2017Trial
- Plasticity under pressure: biology and detection of lineage switch in acute leukemia.Leukemia · 2026Review
- A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia.Nature reviews. Cancer · 2026Review
- Biological and pathogenic roles of major genes harbored in intrachromosomal amplification of chromosome 21 in childhood acute lymphoblastic leukemia (Review).Oncology letters · 2026Review
- Enhancing link prediction in biomedical knowledge graphs with BioPathNet.Nature biomedical engineering · 2026Article
- Personalized reference genome-based pipeline reveals comprehensive haplotype-resolved views of cancer genomes.bioRxiv : the preprint server for biology · 2026Article
- Article
- Chromosomal rearrangement-enhanced mRNA stability drives the oncogenic potential of fusion genes in pediatric leukemia.Haematologica · 2026Article
- The landscape of structural variation in pediatric cancer.Cancer cell · 2026Article
- Reactivation of a TAL1 progenitor cell enhancer region by non-coding somatic variants in T-lineage acute lymphoblastic leukemia.bioRxiv : the preprint server for biology · 2026Article
- SETD4 as a marker of disease burden and treatment response in childhood acute lymphoblastic leukemiaOncology letters · 2026Article
- Comparison of gene fusion detection algorithms reveals frequently overlooked driver fusions in hematologic malignancies.NPJ precision oncology · 2026Article
- Pseudogene Coexpression Networks Reveal a Robust Prognostic Signature for Pediatric B-ALL Survival.Cancer research communications · 2026Article
- Status of IKZF1 Deletions in Diagnose and Relapsed Pediatric B-ALL Patients.Biochemical genetics · 2026Article
142 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
77 authors at 19 institutions in 5 countries.
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Kelly McCastlainDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0001-7868-3049
Hiroki YoshiharaDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Beisi XuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0003-0099-858X
Yunchao ChangDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Michelle L ChurchmanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Gang WuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-1678-5864
Yongjin LiDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Lei WeiDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Ilaria IacobucciDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Yu LiuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Chunxu QuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Ji WenDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Michael EdmonsonDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Debbie Payne-TurnerDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Kerstin B KaufmannPrincess Margaret Cancer Centre, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Shin-Ichiro TakayanagiPrincess Margaret Cancer Centre, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Erno WienholdsPrincess Margaret Cancer Centre, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Esmé WaandersDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-2466-953X
Panagiotis NtziachristosDepartment of Pathology, New York University School of Medicine, New York, New York, USA.
Sofia BakogianniDepartment of Pathology, New York University School of Medicine, New York, New York, USA.
Jingjing WangDepartment of Pathology, New York University School of Medicine, New York, New York, USA.
Iannis AifantisDepartment of Pathology, New York University School of Medicine, New York, New York, USA.
Kathryn G RobertsDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jing MaDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Guangchun SongDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
John EastonDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Heather L MulderDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Xiang ChenDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Scott NewmanDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Xiaotu MaDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Michael RuschDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-5363-1848
Pankaj GuptaDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Kristy BoggsDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Bhavin VadodariaDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
James DaltonDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Yanling LiuDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Marcus L ValentineCytogenetics Core Facility, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Li DingMcDonnell Genome Institute, Washington University, St. Louis, Missouri, USA.ORCID 0000-0003-1517-2975
Charles LuMcDonnell Genome Institute, Washington University, St. Louis, Missouri, USA.
Robert S FultonMcDonnell Genome Institute, Washington University, St. Louis, Missouri, USA.
Lucinda FultonMcDonnell Genome Institute, Washington University, St. Louis, Missouri, USA.
Yashodhan TabibMcDonnell Genome Institute, Washington University, St. Louis, Missouri, USA.
Kerri OchoaMcDonnell Genome Institute, Washington University, St. Louis, Missouri, USA.
Meenakshi DevidasDepartment of Biostatistics, Colleges of Medicine, Public Health and Health Profession, University of Florida, Gainesville, Florida, USA.
Deqing PeiDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Cheng ChengDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jun YangDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-0770-9659
William E EvansDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Mary V RellingDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Ching-Hon PuiDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Sima JehaDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Richard C HarveyDepartment of Pathology, Cancer Research and Treatment Center, University of New Mexico, Albuquerque, New Mexico, USA.
I-Ming L ChenDepartment of Pathology, Cancer Research and Treatment Center, University of New Mexico, Albuquerque, New Mexico, USA.
Cheryl L WillmanDepartment of Pathology, Cancer Research and Treatment Center, University of New Mexico, Albuquerque, New Mexico, USA.
Guido MarcucciDepartment of Hematology and Hematopoietic Cell Transplantation, Gehr Leukemia Center, City of Hope, Duarte, California, USA.
Clara D BloomfieldDivision of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Jessica KohlschmidtDivision of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Krzysztof MrózekDivision of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Elisabeth PaiettaCancer Center, Montefiore Medical Center North Division, Bronx, New York, USA.
Martin S TallmanLeukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Wendy StockSection of Hematology/Oncology, University of Chicago Medical Center, Chicago, Illinois, USA.
Matthew C FosterDivision of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Janis RacevskisDepartment of Medicine (Oncology), Albert Einstein College of Medicine, Montefiore Medical Center, New York, New York, USA.
Jacob M RoweDepartment of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.
Selina LugerAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Steven M KornblauSection of Molecular Hematology and Therapy, Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Sheila A ShurtleffDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Susana C RaimondiDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Elaine R MardisMcDonnell Genome Institute, Washington University, St. Louis, Missouri, USA.
Richard K WilsonMcDonnell Genome Institute, Washington University, St. Louis, Missouri, USA.
John E DickPrincess Margaret Cancer Centre, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-9527-8317
Stephen P HungerDepartment of Pediatrics, Children's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Mignon L LohDepartment of Pediatrics, Benioff Children's Hospital, University of California at San Francisco, San Francisco, California, USA.
James R DowningDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Charles G MullighanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-1871-1850
St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project
St. Jude Children's Research Hospital · USJames S. McDonnell Foundation · USUniversity Health Network · CANew York University · USThe Ohio State University · USUniversity of New Mexico · USAlbert Einstein College of Medicine · USChildren's Hospital of Philadelphia · USCity of Hope · USHoward Hughes Medical Institute · USMemorial Sloan Kettering Cancer Center · USMontefiore Medical Center · USShaare Zedek Medical Center · ILThe University of Texas MD Anderson Cancer Center · USUCSF Benioff Children's Hospital · USUniversity of Chicago Medical Center · USUniversity of Florida · USUniversity of North Carolina at Chapel Hill · USUniversity of Pennsylvania · US
Funding
NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6MX-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4MCOG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5MProject-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer · 2014 to 2026
$167.6MViral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SUZANNE J. BAKER · 1985 to 2026
$166.9MCOG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8MTranslational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI WANCAI YANG · 1985 to 2026
$132.3MChildren's Oncology Group Statistics &Data Center GrantU10CA098413 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ANDERSON, JAMES R · 2003 to 2013
$67.5MWOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1MECOG-ACRIN Biospecimen Bank to Support NCTNU24CA196172 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI STANLEY R. HAMILTON, Scott D Jewell · 2015 to 2026
$41.1MTHE ALLIANCE NCTN BIOREPOSITORY AND BIOSPECIMEN RESOURCEU24CA196171 · NCI · WASHINGTON UNIVERSITY · PI Mine Cicek, Wendy Frankel · 2015 to 2026
$35.0MCPML - Project 3: Genome-wide Studies of Adverse EffectsP50GM115279 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI RELLING, MARY V · 2015 to 2019
$15.1MCCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016058NCI NIH HHS P30 CA021765NCI NIH HHS P30 CA118100NCI NIH HHS R00 CA188293NCI NIH HHS RC1 CA145707NCI NIH HHS U01 CA157937NCI NIH HHS U10 CA098413NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180820NCI NIH HHS U10 CA180827NCI NIH HHS U10 CA180850NCI NIH HHS U10 CA180861NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCI NIH HHS U24 CA114766NCI NIH HHS U24 CA196171NCI NIH HHS U24 CA196172NIGMS NIH HHS P50 GM115279
Abstract
Chromosomal rearrangements deregulating hematopoietic transcription factors are common in acute lymphoblastic leukemia (ALL). Here we show that deregulation of the homeobox transcription factor gene DUX4 and the ETS transcription factor gene ERG is a hallmark of a subtype of B-progenitor ALL that comprises up to 7% of B-ALL. DUX4 rearrangement and overexpression was present in all cases and was accompanied by transcriptional deregulation of ERG, expression of a novel ERG isoform, ERGalt, and frequent ERG deletion. ERGalt uses a non-canonical first exon whose transcription was initiated by DUX4 binding. ERGalt retains the DNA-binding and transactivation domains of ERG, but it inhibits wild-type ERG transcriptional activity and is transforming. These results illustrate a unique paradigm of transcription factor deregulation in leukemia in which DUX4 deregulation results in loss of function of ERG, either by deletion or induced expression of an isoform that is a dominant-negative inhibitor of wild-type ERG function.
Indexed as
Gene DeletionGene Expression Regulation, NeoplasticGene RearrangementAdolescentAdultCell Transformation, NeoplasticGene Expression ProfilingHomeodomain ProteinsHumansPrecursor Cell Lymphoblastic Leukemia-LymphomaProtein IsoformsTranscriptional Regulator ERGYoung AdultDUX4L1 protein, humanERG protein, humanHomeodomain ProteinsProtein IsoformsTranscriptional Regulator ERG
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT00137111ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.