ArticleNature genetics2016
Wheat Fhb1 encodes a chimeric lectin with agglutinin domains and a pore-forming toxin-like domain conferring resistance to Fusarium head blight.
Article in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
134 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-Analysis of the QTLome of Fusarium Head Blight Resistance in Bread Wheat: Refining the Current Puzzle.Frontiers in plant science · 2019Pooled it
- A conserved fungal Egh16-like effector suppresses host defense by disrupting ATP binding of wheat MPK3.Journal of integrative plant biology · 2026Article
- Chromosome-scale assembly of wheat cultivar Sumai 3, a major germplasm source for Fusarium head blight resistance.The plant genome · 2026Article
- Novel allele derived from a Japanese wheat cultivar 'Asakazekomugi' for Fusarium head blight resistance without yield penalty and thousand grain weight reduction.Breeding science · 2026Article
- Accelerating Resistance Breeding: Emerging Methods to Identify and Validate Plant Immunity Genes.Plants (Basel, Switzerland) · 2026Review
- Pre-breeding to establishFrontiers in plant science · 2026Article
- Analysis of a Series of Mutants Highlights Complex Regulation of Fusarium Head Blight Resistance Conferred by Fhb1 Locus in Wheat.Plant biotechnology journal · 2025Article
- Genome-Wide Identification and Expression Profiling of Sugar Transport Protein Response to Fusarium Head Blight in Wheat (Plants (Basel, Switzerland) · 2025Article
- Genetic improvement of FHB and DON resistance by combining the Fhb1 gene with additional resistance QTL in winter wheat population.The plant genome · 2025Article
- Identification of a novel QTL associated with Fusarium head blight resistance on chromosome 3B in common wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Progress and innovations of gene cloning in wheat and its close relatives.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Wheat resistance to Fusarium head blight and breeding strategies.Crop health · 2025Review
- Mutagenesis and analysis of contrasting wheat lines do not support a role for PFT in Fusarium head blight resistance.Nature genetics · 2025Article
- Genome-wide linkage mapping of Fusarium head blight resistance in common wheat (Frontiers in plant science · 2025Article
- Detoxifying bacterial genes for deoxynivalenol epimerization confer durable resistance to Fusarium head blight in wheat.Plant biotechnology journal · 2024Article
- Molecular Investigations to Improve Fusarium Head Blight Resistance in Wheat: An Update Focusing on Multi-Omics Approaches.Plants (Basel, Switzerland) · 2024Review
- Genomic diversity of the Japanese wheat core collection and selection of alleles for agronomic traits in the breeding process.Breeding science · 2024Article
- Identification of candidate genes for Fusarium head blight resistance from QTLs using RIL population in wheat.Plant molecular biology · 2024Article
- Review
- Effects of 2-Phenylethanol on Controlling the Development ofMicroorganisms · 2023Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusarium head blight (FHB), caused by Fusarium graminearum, is a devastating disease of wheat and barley that leads to reduced yield and mycotoxin contamination of grain, making it unfit for human consumption. FHB is a global problem, with outbreaks in the United States, Canada, Europe, Asia and South America. In the United States alone, total direct and secondary economic losses from 1993 to 2001 owing to FHB were estimated at $7.67 billion. Fhb1 is the most consistently reported quantitative trait locus (QTL) for FHB resistance breeding. Here we report the map-based cloning of Fhb1 from a Chinese wheat cultivar Sumai 3. By mutation analysis, gene silencing and transgenic overexpression, we show that a pore-forming toxin-like (PFT) gene at Fhb1 confers FHB resistance. PFT is predicted to encode a chimeric lectin with two agglutinin domains and an ETX/MTX2 toxin domain. Our discovery identifies a new type of durable plant resistance gene conferring quantitative disease resistance to plants against Fusarium species.
Indexed as
Identifiers
27776114What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.