Evidence map›Paper›PMID 27776108›Full record

ArticleNature immunology2016

Programs for the persistence, vigilance and control of human CD8

Pleun Hombrink, Christina Helbig, Ronald A Backer, Berber Piet, Anna E Oja, Regina Stark, Giso Brasser, Aldo Jongejan, René E Jonkers, Benjamin Nota and 5 more

Erratum issuedOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 308 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
308citing papers in PubMed, 1 pooled it
19.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

308 citing papers in PubMed, 1 synthesis or guideline pooled it, 441 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Single-Cell Profiling Identifies Skin-Resident Memory CD4European journal of immunology · 2026
    Article
  10. Review
  11. Review
  12. CD39Science translational medicine · 2026
    Article
  13. HIF-1αImmunity · 2026
    Article
  14. Efficacy of Immune Checkpoint Inhibitors and Oncoviruses in Solid Tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
  15. Article
  16. Article
  17. Evolving role of CD8Frontiers in immunology · 2026
    Review
  18. Origins of CD8 tissue resident memory.Frontiers in immunology · 2026
    Review
  19. Tissue-resident memory T cells reshapeFrontiers in immunology · 2026
    Review
  20. Review

248 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Pleun HombrinkDepartment of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.
Christina HelbigDepartment of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.
Ronald A BackerDepartment of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.
Berber PietDepartment of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands.
Anna E OjaDepartment of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.
Regina StarkDepartment of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.
Giso BrasserDepartment of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.
Aldo JongejanDepartment of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, the Netherlands.
René E JonkersDepartment of Respiratory Medicine, Academic Medical Center, Amsterdam, the Netherlands.
Benjamin NotaDepartment of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.
Onur BasakHubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht, the Netherlands.
Hans C CleversHubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht, the Netherlands.
Perry D MoerlandDepartment of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, the Netherlands.
Derk AmsenDepartment of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.
René A W van LierDepartment of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-3201-7144
Sanquin · NLAmsterdam UMC Location University of Amsterdam · NLRoyal Netherlands Academy of Arts and Sciences · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue-resident memory T cells (T

Indexed as

Immunologic MemoryAnimalsAntigens, CDCD8-Positive T-LymphocytesCells, CulturedFemaleHumansInfluenza A Virus, H3N2 SubtypeIntegrin alpha ChainsLungMaleMiceMice, Inbred C57BLMice, TransgenicMiddle AgedOrthomyxoviridae Infectionsalpha E integrinsAntigens, CDIntegrin alpha ChainsNotch1 protein, mouseNotch2 protein, mouseReceptor, Notch1Receptor, Notch2

Identifiers

PMID27776108
OpenAlexW2533830780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.