Evidence map›Paper›PMID 27775852›Full record

ArticleThe European journal of neuroscience2017

Cotinine administration improves impaired cognition in the mouse model of Fragile X syndrome.

Marta Pardo, Eleonore Beurel, Richard S Jope

Open access · greenAbstract read
In one paragraph

Article in The European journal of neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. TestingFrontiers in molecular neuroscience · 2021
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Nicotinic Acetylcholine Receptor Ligands, Cognitive Function, and Preclinical Approaches to Drug Discovery.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019
    Review
  15. Article
  16. Review
  17. Article
  18. Of Men and Mice: Modeling the Fragile X Syndrome.Frontiers in molecular neuroscience · 2018
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Marta PardoDepartment of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Eleonore BeurelDepartment of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Richard S JopeDepartment of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
University of Miami · US

Funding

LITHIUM EFFECTS ON CHOLINERGIC ACTIVITYR01MH038752 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI JOPE, RICHARD S. · 1985 to 2015
$4.4M
Th17 cells as a new therapeutic target for depressionR01MH104656 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BEUREL, ELEONORE · 2015 to 2024
$3.8M
Adaptive immune system function in depressionR01MH095380 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI JOPE, RICHARD S. · 2012 to 2016
$1.9M
Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3R00MH090236 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BEUREL, ELEONORE · 2012 to 2014
$683k
Effects of lithium on cellular signalingR56MH038752 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JOPE, RICHARD S. · 2011 to 2011
$366k
Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3K99MH090236 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BEUREL, ELEONORE · 2010 to 2011
$179k
NIMH NIH HHS K99 MH090236NIMH NIH HHS R00 MH090236NIMH NIH HHS R01 MH038752NIMH NIH HHS R01 MH095380NIMH NIH HHS R01 MH104656NIMH NIH HHS R56 MH038752
6 · The paper itself

Abstract

Cotinine is the major metabolite of nicotine and has displayed some capacity for improving cognition in mouse models following chronic administration. We tested if acute cotinine treatment is capable of improving cognition in the mouse model of Fragile X syndrome, Fmr1

Indexed as

AnimalsCognitionCotinineFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeGlycogen Synthase Kinase 3 betaHippocampusMaleMiceMice, Inbred C57BLMutation, MissenseNicotinic AgonistsPhosphorylationProtein Processing, Post-TranslationalProto-Oncogene Proteins c-aktSpace PerceptionCotinineFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Glycogen Synthase Kinase 3 betaNicotinic AgonistsProto-Oncogene Proteins c-aktcotinineFragile X syndromeglycogen synthase kinase-3novel object recognitionspatial memory

Identifiers

PMID27775852
PMCPMC5305668
OpenAlexW2535473886

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.