ArticleLaboratory investigation; a journal of technical methods and pathology2016
Knockout of microRNA-21 reduces biliary hyperplasia and liver fibrosis in cholestatic bile duct ligated mice.
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Article in Laboratory investigation; a journal of technical methods and pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
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Who cites it
34 citing papers in PubMed, 53 citations in OpenAlex.
- Therapeutic modulation of the gut microbiota by traditional Chinese medicine in the management of cholestatic liver injury.Frontiers in cellular and infection microbiology · 2026Review
- Dynamic crosstalk between HSCs and liver microenvironment: multicellular interactions in the regulation of liver fibrosis.Frontiers in cell and developmental biology · 2025Review
- Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications.Medical review (2021) · 2024Review
- Role of MicroRNA-21 in Prostate Cancer Progression and Metastasis: Molecular Mechanisms to Therapeutic Targets.Annals of surgical oncology · 2024Review
- Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model.World journal of gastroenterology · 2024Article
- Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness.Journal of cellular and molecular medicine · 2023Review
- Differential expression of microRNAs in bile duct obstruction-induced liver fibrosis and the identification of a novel liver fibrosis marker miR-1295b-3p.Annals of translational medicine · 2023Article
- The Implications of Noncoding RNAs in the Evolution and Progression of Nonalcoholic Fatty Liver Disease (NAFLD)-Related HCC.International journal of molecular sciences · 2022Review
- Liver Graft MicroRNAs Expression in Different Etiology of Acute Jaundice after Living Donor Liver Transplantation.Biology · 2022Article
- MiR-200c-3p targets SESN1 and represses the IL-6/AKT loop to prevent cholangiocyte activation and cholestatic liver fibrosis.Laboratory investigation; a journal of technical methods and pathology · 2022Article
- MicroRNA-21 deficiency suppresses prostate cancer progression through downregulation of the IRS1-SREBP-1 signaling pathway.Cancer letters · 2022Article
- Astragaloside IV Synergizes with Ferulic Acid to Alleviate Hepatic Fibrosis in Bile Duct-Ligated Cirrhotic Rats.Digestive diseases and sciences · 2020Article
- Moesin, an Ezrin/Radixin/Moesin Family Member, Regulates Hepatic Fibrosis.Hepatology (Baltimore, Md.) · 2020Article
- Levels of human cytomegalovirus miR-US25-1-5p and miR-UL112-3p in serum extracellular vesicles from infants with HCMV active infection are significantly correlated with liver damage.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Critical Role of microRNA-21 in the Pathogenesis of Liver Diseases.Frontiers in medicine · 2020Review
- A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing.Annual review of cell and developmental biology · 2019Review
- Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2EBioMedicine · 2019Article
- Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 Knockout Mice via Lethal-7 microRNA.Hepatology (Baltimore, Md.) · 2019Article
- Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- MicroRNAs derived from urinary exosomes act as novel biomarkers in the diagnosis of intrahepatic cholestasis of pregnancy.American journal of translational research · 2019Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Lindsey L KennedyResearch, Central Texas Veterans Health Care System, Temple, TX, USA.
Fanyin MengResearch, Central Texas Veterans Health Care System, Temple, TX, USA.
Julie K VenterDepartment of Medicine and Medical Physiology, Texas A&M Health Science Center, College of Medicine, Temple, TX, USA.
Tianhao ZhouDepartment of Medicine and Medical Physiology, Texas A&M Health Science Center, College of Medicine, Temple, TX, USA.
Walker A KarstensScott & White Digestive Disease Research Center, Baylor Scott & White Health, Temple, TX, USA.
Laura A HargroveScott & White Digestive Disease Research Center, Baylor Scott & White Health, Temple, TX, USA.
Nan WuDepartment of Medicine and Medical Physiology, Texas A&M Health Science Center, College of Medicine, Temple, TX, USA.
Konstantina KyritsiDepartment of Medicine and Medical Physiology, Texas A&M Health Science Center, College of Medicine, Temple, TX, USA.
John GreeneOperational Funds, Baylor Scott & White Health, Texas A&M Health Science Center, College of Medicine, Temple, TX, USA.
Pietro InvernizziHumanitas Clinical and Research Center, Rozzano, Italy.
Francesca BernuzziHumanitas Clinical and Research Center, Rozzano, Italy.
Shannon S GlaserResearch, Central Texas Veterans Health Care System, Temple, TX, USA.
Heather L FrancisResearch, Central Texas Veterans Health Care System, Temple, TX, USA.
Gianfranco AlpiniResearch, Central Texas Veterans Health Care System, Temple, TX, USA.
Texas A&M Health Science Center · USBaylor Scott & White Health · USCentral Texas Veterans Health Care System · USHumanitas University · IT
Funding
GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREER01DK054811 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2000 to 2021
$3.8MThe Paracrine Regulation of Mast Cells During Biliary/Cholangiocyte Repair and DamageR01DK108959 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI FRANCIS, HEATHER L · 2016 to 2024
$2.5MRegulation of Bile Duct Growth in Bile Duct Ligated RatsR01DK062975 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2005 to 2014
$1.9MRole of Sensory Neuropeptides in the Regulation of Biliary FunctionR01DK076898 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2008 to 2016
$1.8MTOWARD THE OPTIMAL TIMING OF INITIATION OF DIALYSISR01DK058411 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CHERTOW, GLENN MATTHEW · 2001 to 2003
$1.8MThe Role of Stem Cell Derived Microvesicles in Cholestatic Liver InjuryR01DK107310 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2015 to 2019
$1.7MAutocrine/Paracrine Regulation of Intrahepatic Bile Duct GrowthI01BX000574 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2009 to 2022
–Mechanisms of synergistic regulation of biliary inflammation and fibrosisI01BX003031 · VA · RLR VA MEDICAL CENTER · PI FRANCIS, HEATHER L · 2016 to 2023
–Role of Mechanosensitive Receptors During Biliary Proliferation and FibrosisI01BX002192 · VA · OLIN TEAGUE VETERANS CENTER · PI GLASER, SHANNON STROUD · 2014 to 2018
–Functional characters of non-coding RNAs in alcoholic liver injuryI01BX001724 · VA · RLR VA MEDICAL CENTER · PI MENG, FANYIN · 2012 to 2024
–BLRD VA I01 BX000574BLRD VA I01 BX001724BLRD VA I01 BX002192BLRD VA I01 BX003031NIDDK NIH HHS R01 DK054811NIDDK NIH HHS R01 DK058411NIDDK NIH HHS R01 DK062975NIDDK NIH HHS R01 DK076898NIDDK NIH HHS R01 DK107310NIDDK NIH HHS R01 DK108959
Abstract
Cholestasis is a condition that leads to chronic hepatobiliary inflammation, fibrosis, and eventually cirrhosis. Many microRNAs (miRs) are known to have a role in fibrosis progression; however, the role of miR-21 during cholestasis remains unknown. Therefore, the aim of this study was to elucidate the role of miR-21 during cholestasis-induced biliary hyperplasia and hepatic fibrosis. Wild-type (WT) and miR-21
Indexed as
Disease Models, AnimalUp-RegulationAnimalsApoptosisBile Ducts, IntrahepaticBiomarkersCell LineCell ProliferationCells, CulturedCholestasis, IntrahepaticDisease ProgressionGene Expression RegulationHepatic Stellate CellsHumansHyperplasiaLiver CirrhosisBiomarkersMicroRNAsMIRN21 microRNA, humanMIRN21 microRNA, mouseSmad7 Protein
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