ArticleMolecules (Basel, Switzerland)2016
Potential Anticancer Effects of Polyphenols from Chestnut Shell Extracts: Modulation of Cell Growth, and Cytokinomic and Metabolomic Profiles.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 70 citations in OpenAlex.
- Valorization of Chestnut By-Products: Extraction, Bioactivity, and Applications of Shells, Spiny Burs, and Leaves.Life (Basel, Switzerland) · 2026Review
- Chestnut (Heliyon · 2025Article
- Antioxidant Bio-Compounds from Chestnut Waste: A Value-Adding and Food Sustainability Strategy.Foods (Basel, Switzerland) · 2024Article
- Beneficial Effects ofPlants (Basel, Switzerland) · 2024Review
- Review
- Effect of Chestnut (Molecules (Basel, Switzerland) · 2023Article
- The Southern European Atlantic Diet and Its Supplements: The Chemical Bases of Its Anticancer Properties.Nutrients · 2023Review
- Chemical and Bioactive Screening of Green Polyphenol-Rich Extracts from Chestnut By-Products: An Approach to Guide the Sustainable Production of High-Added Value Ingredients.Foods (Basel, Switzerland) · 2023Article
- Bioactive Compounds and Antioxidant Composition of Nut Bars with Addition of Various Edible Insect Flours.Molecules (Basel, Switzerland) · 2023Article
- Metabolic Profiling of Chestnut Shell (Biomolecules · 2022Article
- Innovative Application of Metabolomics on Bioactive Ingredients of Foods.Foods (Basel, Switzerland) · 2022Review
- Inner Shell of the Chestnut (Nutrients · 2022Article
- Medicinal Plants for the Treatment of Gastrointestinal Cancers From the Metabolomics Perspective.Frontiers in pharmacology · 2022Review
- New Properties and Mitochondrial Targets of Polyphenol Agrimoniin as a Natural Anticancer and Preventive Agent.Pharmaceutics · 2021Article
- Effect of Roasting, Boiling, and Frying Processing on 29 Polyphenolics and Antioxidant Activity in Seeds and Shells of Sweet Chestnut (Plants (Basel, Switzerland) · 2021Article
- Chestnut Shell Tannins: Effects on Intestinal Inflammation and Dysbiosis in Zebrafish.Animals : an open access journal from MDPI · 2021Article
- Polyphenol Profiling of Chestnut Pericarp, Integument and Curing Water Extracts to Qualify These Food By-Products as a Source of Antioxidants.Molecules (Basel, Switzerland) · 2021Article
- Antioxidant and In Vitro Preliminary Anti-Inflammatory Activity ofAntioxidants (Basel, Switzerland) · 2021Article
- Leaves and Spiny Burs ofMetabolites · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, a hydroalcoholic chestnut shell extract was characterized and tested on six different human cell lines. Gallic, ellagic, and syringic acids were the most abundant non-condensed compounds in the chestnut extract, as determined by high performance liquid chromatography (HPLC). Tannins were mainly represented by condensed monomeric units of epigallocatechin and catechin/epicatechin. After 48 h of treatment, only the human hepatoblastoma HepG2 cells reached an inhibition corresponding to IC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.