Evidence map›Paper›PMID 27775567›Full record

ReviewInternational journal of molecular sciences2016

A Proteogenomic Approach to Understanding MYC Function in Metastatic Medulloblastoma Tumors.

Jerome A Staal, Yanxin Pei, Brian R Rood

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Jerome A StaalMultiple Sclerosis Department, Florey Institute of Neuroscience and Mental Health, Melbourne, VIC 3052, Australia. jstaal@florey.edu.au.
Yanxin PeiCenter for Cancer and Immunology Research, Children's National Medical Center, Washington, DC 20010, USA. ypei@childrensnational.org.
Brian R RoodCenter for Cancer and Immunology Research, Children's National Medical Center, Washington, DC 20010, USA. brood@childrensnational.org.
Children's National · US

Funding

Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2016 to 2020
$5.9M
NICHD NIH HHS U54 HD090257
6 · The paper itself

Abstract

Brain tumors are the leading cause of cancer-related deaths in children, and medulloblastoma is the most prevalent malignant childhood/pediatric brain tumor. Providing effective treatment for these cancers, with minimal damage to the still-developing brain, remains one of the greatest challenges faced by clinicians. Understanding the diverse events driving tumor formation, maintenance, progression, and recurrence is necessary for identifying novel targeted therapeutics and improving survival of patients with this disease. Genomic copy number alteration data, together with clinical studies, identifies

Indexed as

Gene Expression Regulation, NeoplasticAnimalsCerebellar NeoplasmsChildGene DosageGenotypeHumansMedulloblastomaMiceNeoplasm Recurrence, LocalPhenotypeProteogenomicsProto-Oncogene Proteins c-mycRisk FactorsTumor Suppressor Protein p53MYC protein, humanProto-Oncogene Proteins c-mycTP53 protein, humanTumor Suppressor Protein p53medulloblastomaMYCquantitative proteomics

Identifiers

PMID27775567
PMCPMC5085772
OpenAlexW2537156614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.