ArticleScientific reports2016
Genetic analysis of innate immunity in Behcet's disease identifies an association with IL-37 and IL-18RAP.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Associations between interleukin-37 gene polymorphisms and susceptibility and clinical outcomes of rheumatoid arthritis: a meta-analysis and systematic review.BMC rheumatology · 2026Pooled it
- Association betweenThe Journal of international medical research · 2021Pooled it
- Pooled it
- Relationship between interleukin-37 genetic polymorphisms and HBV-related liver disease in a Chinese Han cohort.Journal of applied biomedicine · 2025Article
- Interleukin-37 polymorphism (rs3811047) in Egyptian patients with ulcerative colitis.Molecular biology reports · 2025Article
- Role of Interleukin 37 and its polymorphism (rs3811047) in children with type I diabetes.Molecular biology reports · 2025Article
- Biology of interleukin-37 and its role in autoimmune diseases (Review).Experimental and therapeutic medicine · 2022Review
- Interleukin-37 gene polymorphism and susceptibility to coronavirus disease 19 among Iraqi patients.Meta gene · 2022Article
- Genetics in Behcet's Disease: An Update Review.Frontiers in ophthalmology · 2022Review
- Association of theDiagnostics (Basel, Switzerland) · 2021Article
- Mimicking Behçet's disease: GM-CSF gain of function mutation in a family suffering from a Behçet's disease-like disorder marked by extreme pathergy.Clinical and experimental immunology · 2021Article
- Functional Genetic Polymorphisms in the IL1RL1-IL18R1 Region Confer Risk for Ocular Behçet's Disease in a Chinese Han Population.Frontiers in genetics · 2020Article
- Letter to Editor: Serum interleukin-37 level and interleukin-37 gene polymorphism in patients with Behçet disease.Clinical rheumatology · 2019Article
- Serum interleukin-37 level and interleukin-37 gene polymorphism in patients with Behçet disease.Clinical rheumatology · 2019Article
- Association ofThe British journal of ophthalmology · 2018Article
- Associations betweenOncotarget · 2017Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-1 (IL-1) and the IL-1 receptor (IL-1R) family play an important role in the pathogenesis of inflammatory diseases. This study aimed to investigate the association between single nucleotide polymorphisms (SNP) of IL-1 and IL-1R family genes with Vogt-Koyanagi-Harada (VKH) and Behcet's disease (BD) in Han Chinese. The case-control study was divided into two stages and included 419 VKH cases, 1063 BD cases and 1872 healthy controls. The MassARRAY platform (Sequenom), iPLEX Gold Assay and TaqMan SNP assays were used to score genotypes of 24 SNPs. The expression of IL-37 and IL-18Rap was measured by ELISA and real-time PCR in genotyped healthy individuals. A significantly lower frequency of the AG genotype, and a higher frequency of the GG genotype and G allele of IL-37/rs3811047 were observed in BD as compared to controls. AA genotype and A allele frequency of IL-18RAP/rs2058660 was significantly decreased in BD as compared to controls. Functional studies performed in healthy controls showed that rs3811047 AG genotype carriers had a higher IL-37 gene expression in peripheral blood mononuclear cells (PBMCs) than GG carriers. GG carriers showed a higher cytokine expression as compared to AG carriers. No association was detected between the tested SNPs and VKH.
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