Evidence map›Paper›PMID 27775046›Full record

ArticleScientific reports2016

Immune Responses to an Oral Cholera Vaccine in Internally Displaced Persons in South Sudan.

Anita S Iyer, Malika Bouhenia, John Rumunu, Abdinasir Abubakar, Randon J Gruninger, Jane Pita, Richard Lako Lino, Lul L Deng, Joseph F Wamala, Edward T Ryan and 7 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Diagnosis, Management, and Future Control of Cholera.Clinical microbiology reviews · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. High Prevalence ofThe American journal of tropical medicine and hygiene · 2018
    Article
  19. Article
  20. High Hepatitis E Seroprevalence Among Displaced Persons in South Sudan.The American journal of tropical medicine and hygiene · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 4 countries.

Anita S IyerDivision of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Malika BouheniaWorld Health Organization, Juba, South Sudan.
John RumunuRepublic of South Sudan Ministry of Health, Juba, South Sudan.
Abdinasir AbubakarWorld Health Organization, Juba, South Sudan.
Randon J GruningerDivision of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Jane PitaWorld Health Organization, Juba, South Sudan.
Richard Lako LinoRepublic of South Sudan Ministry of Health, Juba, South Sudan.
Lul L DengRepublic of South Sudan Ministry of Health, Juba, South Sudan.
Joseph F WamalaWorld Health Organization, Juba, South Sudan.
Edward T RyanDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
Stephen MartinWorld Health Organization, Geneva, Switzerland.
Dominique LegrosWorld Health Organization, Geneva, Switzerland.
Justin LesslerDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
David A SackDepartment of International Health, Johns Hopkins University, Baltimore, MD, USA.
Francisco J LuqueroDepartment of International Health, Johns Hopkins University, Baltimore, MD, USA.
Daniel T LeungDivision of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Andrew S AzmanDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USUniversity of Juba · SSFederal Ministry of Health · SDUniversity of Utah · USWorld Health Organization · CHMassachusetts General Hospital · US

Funding

O-Specific Polysaccharide Responses and CholeraR37AI106878 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Edward T. Ryan · 2020 to 2026
$5.1M
O-Specific Polysaccharide Responses and CholeraR01AI106878 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RYAN, EDWARD T. · 2014 to 2018
$3.7M
Immune Responses to Vibrio Cholerae in ChildrenK08AI100923 · NIAID · UNIVERSITY OF UTAH · PI LEUNG, DANIEL TED · 2012 to 2016
$686k
NIAID NIH HHS K08 AI100923NIAID NIH HHS R01 AI106878NIAID NIH HHS R37 AI106878World Health Organization 001
6 · The paper itself

Abstract

Despite recent large-scale cholera outbreaks, little is known about the immunogenicity of oral cholera vaccines (OCV) in African populations, particularly among those at highest cholera risk. During a 2015 preemptive OCV campaign among internally displaced persons in South Sudan, a year after a large cholera outbreak, we enrolled 37 young children (1-5 years old), 67 older children (6-17 years old) and 101 adults (≥18 years old), who received two doses of OCV (Shanchol) spaced approximately 3 weeks apart. Cholera-specific antibody responses were determined at days 0, 21 and 35 post-immunization. High baseline vibriocidal titers (>80) were observed in 21% of the participants, suggesting recent cholera exposure or vaccination. Among those with titers ≤80, 90% young children, 73% older children and 72% adults seroconverted (≥4 fold titer rise) after the 1

Indexed as

Administration, OralAdolescentAntibodies, BacterialAntibody FormationChildChild, PreschoolCholeraCholera VaccinesDisease OutbreaksFemaleHumansInfantInfant, NewbornMaleSouth SudanVaccinationAntibodies, BacterialCholera VaccinesshancholVaccines, Inactivated

Identifiers

PMID27775046
PMCPMC5075787
OpenAlexW2535900528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.