Observational studyEthnicity & health2017
Does one size fit all? The role of body mass index and waist circumference in systemic inflammation in midlife by race and gender.
Observational study in Ethnicity & health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- The Effect of Resistance Training on the Rehabilitation of Elderly Patients with Sarcopenia: A Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- A Meta-Analysis of the Effects of Different Training Modalities on the Inflammatory Response in Adolescents with Obesity.International journal of environmental research and public health · 2022Pooled it
- Abdominal Obesity and Risk of Hip Fracture: A Systematic Review and Meta-Analysis of Prospective Studies.Advances in nutrition (Bethesda, Md.) · 2017Pooled it
- Cardiometabolic impact of dolutegravir as second-line therapy: secondary analysis of a randomized controlled trial.AIDS (London, England) · 2026Trial
- Assessing the Impact of Estimated Glucose Disposal Rate (eGDR) on Cognitive Function in Older Adults: A NHANES-Based Machine Learning Study.CNS neuroscience & therapeutics · 2025Article
- Fracture Risk Assessment in Metabolic Syndrome in Terms of Secondary Osteoporosis Potential. A Narrative Review.Calcified tissue international · 2025Review
- Associations between new obesity indices and abnormal bone density in type 2 diabetes mellitus patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Circulating Inflammatory Biomarkers Predict Pain Change Following Exercise-Induced Shoulder Injury: Findings From the Biopsychosocial Influence on Shoulder Pain Preclinical Trial.The journal of pain · 2023Article
- Dysfunction of the hypothalamic-pituitary adrenal axis and its influence on aging: the role of the hypothalamus.Scientific reports · 2023Article
- Uncovering Novel Biomarkers of Inflammation as Potential Screening Targets of Disease Risk in Healthcare Shift Workers: A Pilot Study.International journal of nursing and health care research · 2023Article
- General and abdominal obesity operate differently as influencing factors of fracture risk in old adults.iScience · 2022Article
- Management of BMI Is a Potential New Approach for the Prevention of Idiopathic Pulmonary Fibrosis.Frontiers in genetics · 2022Article
- Shift Work Predicts Increases in Lipopolysaccharide-Binding Protein, Interleukin-10, and Leukocyte Counts in a Cross-Sectional Study of Healthy Volunteers Carrying Low-Grade Systemic Inflammation.International journal of environmental research and public health · 2021Article
- Abdominal Obesity in Comparison with General Obesity and Risk of Developing Rheumatoid Arthritis in Women.The Journal of rheumatology · 2021Article
- Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia.Scientific reports · 2020Article
- Biopsychosocial factors associated with a current depressive episode in diabetes: the ELSA-Brasil study.Diabetic medicine : a journal of the British Diabetic Association · 2020Article
- Body Mass Index and Total Symptom Burden in Myeloproliferative Neoplasms Discovery of a U-shaped Association.Cancers · 2020Article
- Neuroinflammation and White Matter Alterations in Obesity Assessed by Diffusion Basis Spectrum Imaging.Frontiers in human neuroscience · 2019Article
- Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial.Nutrition & metabolism · 2019Article
- Circulating cytokine levels are associated with symptoms of depression and anxiety among people with alcohol and drug use disorders.Journal of neuroimmunology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveThis study investigates the associations of body mass index (BMI) and waist circumference (WC) with markers of systemic inflammation in midlife by race and gender.
designData were obtained from the Survey of Midlife in the United States, a cross-sectional, observational study of Americans 35 years old or older (White men: N = 410; White women: N = 490; Black men: N = 58; Black women: N = 117). Inflammation was measured by concentrations of fibrinogen and C-reactive protein (CRP) in fasting plasma and concentrations of E-selectin and interleukin-6 (IL-6) in fasting serum. Anthropometric data were used to obtain BMI and WC. Socio-demographic and health-related factors were assessed with a survey. Multivariate models by race and gender were estimated to test the roles of BMI and WC for each inflammation marker.
resultsCompared to White men, Black women have higher BMI and higher levels of all four inflammation markers; White women have lower BMI, lower WC, and lower E-selectin and fibrinogen but higher CRP; and Black men have higher fibrinogen. After adjusting for socio-demographic and health-related covariates as well as perceived discrimination, WC is associated with all four markers of inflammation among White men and women; with three markers (fibrinogen, CRP, and IL-6) of inflammation among Black women; and with CRP (and marginally with fibrinogen and E-selectin) among Black men. BMI is associated with higher CRP and fibrinogen among Black men (marginally so for White men) but not for women of either race.
conclusionsWC shows more consistent associations with inflammation markers than BMI, although the relationships vary by inflammation marker and population group. Our findings suggest that WC is a risk factor for systemic inflammation among White and Black men and women, and BMI is an additional risk factor for Black men.
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Registered trials
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