Evidence map›Paper›PMID 27774611›Full record

ArticleHepatology (Baltimore, Md.)2017

CD4

Dana Tedesco, Manoj Thapa, Sanjeev Gumber, Elizabeth J Elrod, Khalidur Rahman, Chris C Ibegbu, Joseph F Magliocca, Andrew B Adams, Frank Anania, Arash Grakoui

Abstract read
In one paragraph

Article in Hepatology (Baltimore, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Pathogenesis of Autoimmune Hepatitis-Cellular and Molecular Mechanisms.International journal of molecular sciences · 2021
    Review
  4. Review
  5. Article
  6. Foxp3+ Regulatory T Cells Inhibit CClFrontiers in immunology · 2020
    Article
  7. Review
  8. Environmental peer pressure: CD4Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Dana TedescoEmory Vaccine Center, Yerkes National Primate Research Center, Division of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.
Manoj ThapaEmory Vaccine Center, Yerkes National Primate Research Center, Division of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.
Sanjeev GumberDivision of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.
Elizabeth J ElrodEmory Vaccine Center, Yerkes National Primate Research Center, Division of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.
Khalidur RahmanDivision of Digestive Diseases, Emory University School of Medicine, Atlanta, GA.
Chris C IbegbuEmory Vaccine Center, Yerkes National Primate Research Center, Division of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.
Joseph F MaglioccaDepartment of Surgery, Emory University School of Medicine, Atlanta, GA.
Andrew B AdamsDepartment of Surgery, Emory University School of Medicine, Atlanta, GA.
Frank AnaniaDivision of Digestive Diseases, Emory University School of Medicine, Atlanta, GA.
Arash GrakouiEmory Vaccine Center, Yerkes National Primate Research Center, Division of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.
Emory University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
Mechanisms of hepatitis C virus persistenceR01AI070101 · NIAID · EMORY UNIVERSITY · PI GRAKOUI, ARASH · 2006 to 2016
$3.9M
The Role of Leptin in Liver FibrogenesisR01DK062092 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI ANANIA, FRANK A · 2003 to 2016
$3.9M
T cell Immunity and the Outcome of Acute HCV InfectionR01AI126890 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GRAKOUI, ARASH, WALKER, CHRISTOPHER M. · 2016 to 2020
$3.7M
T cell compartmentalization and antiviral responseR01AI124680 · NIAID · EMORY UNIVERSITY · PI GRAKOUI, ARASH, ZHU, CHENG · 2016 to 2020
$3.2M
Advanced Research Training in Transplantation ScienceT32AI070081 · NIAID · EMORY UNIVERSITY · PI Mandy L Ford · 2006 to 2026
$3.1M
Role of Inflammatory B cells in Liver Fibrosis and Chronic HCV InfectionF32DK101163 · NIDDK · EMORY UNIVERSITY · PI THAPA, MANOJ · 2014 to 2015
$113k
Mechanisms of glucagon-like peptide 1 (GLP-1) in fatty liver diseaseI01BX001746 · VA · VETERANS HEALTH ADMINISTRATION · PI ANANIA, FRANK A · 2013 to 2016
–
BLRD VA I01 BX001746NCRR NIH HHS P51 RR000165NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI070101NIAID NIH HHS R01 AI124680NIAID NIH HHS R01 AI126890NIAID NIH HHS T32 AI070081NIDDK NIH HHS F32 DK101163NIDDK NIH HHS R01 DK062092NIH HHS P51 OD011132
6 · The paper itself

Abstract

Persistent hepatotropic viral infections are a common etiologic agent of chronic liver disease. Unresolved infection can be attributed to nonfunctional intrahepatic CD8+ T-cell responses. In light of dampened CD8

conclusionLiver disease elicits alterations in the intrahepatic CD4

Indexed as

Analysis of VarianceAnimalsCD8-Positive T-LymphocytesCells, CulturedChronic DiseaseDisease Models, AnimalEnzyme-Linked Immunosorbent AssayEnzyme-Linked Immunospot AssayFlow CytometryForkhead Transcription FactorsHepatitis C, ChronicHepatocytesHumansImmunoglobulin GImmunohistochemistryLiver CirrhosisForkhead Transcription FactorsImmunoglobulin G

Identifiers

PMID27774611
PMCPMC5258825
OpenAlexW2545921342

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.