ArticlePsychopharmacology2017
Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline.
Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- Maximising translational value of the Iowa gambling task in preclinical studies through the use of the rodent touchscreen.Frontiers in psychiatry · 2025Review
- Exploration of Positive and Negative Schizophrenia Symptom Heterogeneity and Establishment of Symptom-Related miRNA-mRNA Regulatory Network: Based on Transcriptome Sequencing Data.Molecular neurobiology · 2024Article
- Pharmacological inhibition of the MAP2K7 kinase in human disease.Frontiers in oncology · 2024Review
- Whole transcriptome analysis in offspring whose fathers were exposed to a developmental insult: a novel avian model.Scientific reports · 2023Article
- Zebrafish MAP2K7 Simultaneously Enhances Host IRF7 Stability and Degrades Spring Viremia of Carp Virus P Protein via Ubiquitination Pathway.Journal of virology · 2023Article
- Uncovering novel regulators of memory using C. elegans genetic and genomic analysis.Biochemical Society transactions · 2023Review
- Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients.Schizophrenia (Heidelberg, Germany) · 2022Article
- The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task.Disease models & mechanisms · 2022Article
- BDNF and JNK Signaling Modulate Cortical Interneuron and Perineuronal Net Development: Implications for Schizophrenia-Linked 16p11.2 Duplication Syndrome.Schizophrenia bulletin · 2021Article
- Behavioral Tasks Evaluating Schizophrenia-like Symptoms in Animal Models: A Recent Update.Current neuropharmacology · 2021Review
- Effects of Antipsychotic Drugs: Cross Talk Between the Nervous and Innate Immune System.CNS drugs · 2020Review
- Map2k7 Haploinsufficiency Induces Brain Imaging Endophenotypes and Behavioral Phenotypes Relevant to Schizophrenia.Schizophrenia bulletin · 2020Article
- JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk.Journal of neuroinflammation · 2019Article
- Novel transcriptional networks regulated by CLOCK in human neurons.Genes & development · 2017Article
- Adaptive combination of Bayes factors as a powerful method for the joint analysis of rare and common variants.Scientific reports · 2017Article
- Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7.Scientific reports · 2017Article
- Immediate-Early Genes Modulation by Antipsychotics: Translational Implications for a Putative Gateway to Drug-Induced Long-Term Brain Changes.Frontiers in behavioral neuroscience · 2017Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
rationaleMembers of the c-Jun N-terminal kinase (JNK) family of mitogen-activated protein (MAP) kinases, and the upstream kinase MKK7, have all been strongly linked with synaptic plasticity and with the development of the neocortex. However, the impact of disruption of this pathway on cognitive function is unclear.
objectiveIn the current study, we test the hypothesis that reduced MKK7 expression is sufficient to cause cognitive impairment.
methodsAttentional function in mice haploinsufficient for Map2k7 (Map2k7
resultsOnce stable performance had been achieved, Map2k7
conclusionsOverall, Map2k7 haploinsufficiency causes a distinctive pattern of cognitive impairment strongly suggestive of an inability to sustain attention, in accordance with those seen in psychiatric patients carrying out similar tasks. This may be important for understanding the mechanisms of cognitive dysfunction in clinical populations and highlights the possibility of treating some of these deficits with minocycline.
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