Evidence map›Paper›PMID 27774523›Full record

ArticleJournal of immunology research and therapy2016

Interferon-Gamma Receptor Signaling Plays an Important Role in Restraining Murine Ovarian Tumor Progression.

Guanglin Bian, Nicholas D Leigh, Wei Du, Lei Zhang, Li Li, Xuefang Cao

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of immunology research and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Guanglin BianDepartment of Immunology, Roswell Park Cancer Institute, Buffalo, USA.
Nicholas D LeighDepartment of Immunology, Roswell Park Cancer Institute, Buffalo, USA.
Wei DuDepartment of Immunology, Roswell Park Cancer Institute, Buffalo, USA.
Lei ZhangThe fourth affiliated hospital, Hebei Medical University, Shijiazhuang, China.
Li LiThe fourth affiliated hospital, Hebei Medical University, Shijiazhuang, China.
Xuefang CaoDepartment of Immunology, Roswell Park Cancer Institute, Buffalo, USA.
Roswell Park Comprehensive Cancer Center · US

Funding

MULTIDISCIPLINARY APPROACHES TUMOR IMMUNOLOGYT32CA085183 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Scott I. Abrams · 2001 to 2026
$3.1M
Targeting Beta-Adrenergic Signaling to Control GVH and GVL ResponsesR21CA202358 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI CAO, XUEFANG · 2016 to 2017
$435k
NCI NIH HHS R21 CA202358NCI NIH HHS T32 CA085183
6 · The paper itself

Abstract

Immune cell-derived cytotoxic pathways have been implicated in antitumor immune responses. The goal of this study is to characterize how these cytotoxic pathways influence ovarian cancer development. We have utilized the TgMISIIR-TAg transgenic mouse model which expresses the transforming SV40 TAg in the ovary, leading to spontaneous development of ovarian tumors that closely mimic human epithelial ovarian cancer. To test how perforin (Prf1), granzyme B (GzmB) and interferon-gamma (IFNg) impact tumor occurrence and progression, we bred the TgMISIIR-TAg transgene into

Indexed as

Cytotoxic pathwaysGranzyme B (GzmB)Interferon-gamma (IFNg)Ovarian cancerPerforin (Prf1)Tumor immunity

Identifiers

PMID27774523
PMCPMC5070605
OpenAlexW2539578918

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.