Evidence map›Paper›PMID 27774522›Full record

ArticleInternal medicine review (Washington, D.C. : Online)

The Effect of Treatment with Resiniferatoxin and Capsaicin on Dynamic Weight Bearing Measures and Evoked Pain Responses in a Chronic Inflammatory Arthritis Murine Model.

Joseph Bert, Maren L Mahowald, Sandra Frizelle, Christopher W Dorman, Sonia C Funkenbusch, Hollis E Krug

Open access · diamondAbstract read
PubMed Full text at PMC
In one paragraph

Article in Internal medicine review (Washington, D.C. : Online). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Joseph BertRheumatology Fellowship Training Program, University of Minnesota Medical School, Minneapolis, MN, USA.
Maren L MahowaldMinneapolis VA Health Care System, Minneapolis, MN, USA; University of Minnesota Medical School, Minneapolis, MN, USA.
Sandra FrizelleMinneapolis VA Health Care System, Minneapolis, MN, USA.
Christopher W DormanMinneapolis VA Health Care System, Minneapolis, MN, USA.
Sonia C FunkenbuschMinneapolis VA Health Care System, Minneapolis, MN, USA.
Hollis E KrugMinneapolis VA Health Care System, Minneapolis, MN, USA; University of Minnesota Medical School, Minneapolis, MN, USA.
University of Minnesota Medical Center · US

Funding

Effect of Articular Neurotoxin on Joint Pain and Neurochemical SignatureI01RX000379 · VA · MINNEAPOLIS VA MEDICAL CENTER · PI KRUG, HOLLIS ELAINE, MAHOWALD, MAREN LAWSON · 2012 to 2022
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RRD VA I01 RX000379
6 · The paper itself

Abstract

objectiveCapsaicin (CAP) and Resiniferatoxin (RTX) are vanilloid receptor agonists that can normalize Evoked Pain Scores (EPS) and Automated Dynamic Weight Bearing (ADWB) measures in murine acute inflammatory arthritis when given by intra-articular (IA) injection. To determine whether these vanilloid receptor agonists have benefit in Complete Freund's Adjuvant (CFA) induced chronic inflammatory arthritis pain, we measured changes in ADWB and EPS in arthritic mice with and without treatment with IA CAP and RTX. METHODS AND MATERIALS: Chronic inflammatory arthritis was produced by IA injection of 30 µl of Complete Freund's Adjuvant (CFA) into the left knee of C57BL6 male mice 3 weeks prior to pain behavior testing. Mice were injected with either low or high dose IA RTX (10µl of 0.001 or 0.003%), or IA CAP (10 µL of 0.01%) 7 days prior to pain behavior testing.

resultsChronic Inflammatory arthritis pain produced increased EPS and reduced ADWB measures for weight bearing in the affected limb of arthritic mice compared to naïve mice. ADWB measurements for time in CFA when compared with Naive were not significantly different, but suggested off-loading the arthritic limb to the normal limb. Treatment with IA CAP or RTX 7 days prior to pain behavior testing produced significant improvement in EPS but no improvement in ADWB measures. Neither IA CAP nor IA RTX had any impact on EPS or ADWB measurements in non-arthritic mice when given 7 days prior to pain behavioral testing.

conclusionUsing ADWB and EPS, we quantified pain in a murine chronic inflammatory arthritis model. IA CFA caused a significant increase in EPS and decreased ADWB measures in the affected limb. Treatment with IA RTX and CAP produced significant improvement in EPS in mice with mono-articular inflammatory arthritis. IA vanilloid treatment produced no improvement in ADWB measurements for weight and for time.

Indexed as

capsaicinintra-articularPainresiniferatoxinvanilloid

Identifiers

PMID27774522
PMCPMC5070479
OpenAlexW2540643726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.