ArticleScience advances2016
Social transfer of pain in mice.
Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
84 citing papers in PubMed, 161 citations in OpenAlex.
- Social rank modulates empathic pain via Galntl6Molecular psychiatry · 2026Article
- 5-HTZoological research · 2026Article
- Chronic ethanol drinking alters medial prefrontal cortex and nucleus accumbens astrocyte translatome and extracellular matrix glycosaminoglycans.Neuropharmacology · 2026Article
- The Anterior Cingulate Cortex and Prosocial Behavior toward Others in Negative State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Pupillometry and brain-wide c-Fos mapping uncover multimodal mirror emotional contagion related networks of mice.iScience · 2026Article
- Effects of electroacupuncture at Zusanli on pain-perception-related brain nuclei in KOA mice: a study on cortical and subcortical c-fos expression.Behavioral and brain functions : BBF · 2026Article
- Light-aversion and cephalic allodynia in an intravenous CGRP model of migraine-like behaviour in male and female rats.The journal of headache and pain · 2026Article
- Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology.Annals of neurology · 2026Review
- Sex Differences in Pain Contagion Determined by the Balance of Oxytocin and Corticosterone in the Anterior Cingulate Cortex in Rodents.Neuroscience bulletin · 2025Article
- Alcohol use disorder-associated pain: clinical and preclinical evidence.Alcohol (Fayetteville, N.Y.) · 2025Review
- Central thyroid hormone receptor-beta: Sensitivity to alcohol and a role in regulating alcohol drinking.Hormones and behavior · 2025Article
- Dysfunction of the paraventricular thalamus-prelimbic cortex circuit underlies maternal separation-induced deficits in contagious pain.Science advances · 2025Article
- Modulatory Effects of CB1 Receptors on Cognitive Performance in Rat Model of Empathic Pain.Basic and clinical neuroscience · 2025Article
- Dorsal raphe GABA-ergic neurons regulate the susceptibility to social transfer of pain in mice.Acta pharmacologica Sinica · 2025Article
- Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Social Avoidance of Mice in Pain in Naturalistic Conditions.Affective science · 2025Article
- VTA is the Key to Pain Resilience in Empathic Behavior.Neuroscience bulletin · 2025Article
- Rescue-like behavior in a bystander mouse toward anesthetized conspecifics promotes arousal via a tongue-brain connection.Science advances · 2025Article
- Article
- Airway sensory systems: breathing new life into microbiota-brain communication.Frontiers in cellular neuroscience · 2025Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A complex relationship exists between the psychosocial environment and the perception and experience of pain, and the mechanisms of the social communication of pain have yet to be elucidated. The present study examined the social communication of pain and demonstrates that "bystander" mice housed and tested in the same room as mice subjected to inflammatory pain or withdrawal from morphine or alcohol develop corresponding hyperalgesia. Olfactory cues mediate the transfer of hyperalgesia to the bystander mice, which can be measured using mechanical, thermal, and chemical tests. Hyperalgesia in bystanders does not co-occur with anxiety or changes in corticosterone and cannot be explained by visually dependent emotional contagion or stress-induced hyperalgesia. These experiments reveal the multifaceted relationship between the social environment and pain behavior and support the use of mice as a model system for investigating these factors. In addition, these experiments highlight the need for proper consideration of how experimental animals are housed and tested.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.