ArticleHypoxia (Auckland, N.Z.)2015
Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival.
Article in Hypoxia (Auckland, N.Z.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Hypoxic Neuroinflammation in the Pathogenesis of Multiple Sclerosis.Brain sciences · 2025Review
- Quiescent Adult Neural Stem Cells: Developmental Origin and Regulatory Mechanisms.Neuroscience bulletin · 2024Review
- Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood-brain barrier impairment.Acta neuropathologica communications · 2023Article
- The Brain at High Altitude: From Molecular Signaling to Cognitive Performance.International journal of molecular sciences · 2023Review
- The impact of hypoxia on blood-brain, blood-CSF, and CSF-brain barriers.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Review
- Neurotrophins Time Point Intervention after Traumatic Brain Injury: From Zebrafish to Human.International journal of molecular sciences · 2021Review
- Signs of Chronic Hypoxia Suggest a Novel Pathophysiological Event in α-Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- The carotid body: a physiologically relevant germinal niche in the adult peripheral nervous system.Cellular and molecular life sciences : CMLS · 2019Review
- Mitochondrial Complex I Function Is Essential for Neural Stem/Progenitor Cells Proliferation and Differentiation.Frontiers in neuroscience · 2019Article
- Oxygen sensing and stem cell activation in the hypoxic carotid body.Cell and tissue research · 2018Review
- Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia.EMBO reports · 2018Article
- Manipulation of neural progenitor fate through the oxygen sensing pathway.Methods (San Diego, Calif.) · 2018Review
- Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo.PloS one · 2017Article
- Carotid body oxygen sensing and adaptation to hypoxia.Pflugers Archiv : European journal of physiology · 2016Review
- Resistance of glia-like central and peripheral neural stem cells to genetically induced mitochondrial dysfunction--differential effects on neurogenesis.EMBO reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive respiratory disorders, is a common medical condition that can produce serious neurological alterations. However, the pathogenesis of this phenomenon is unknown. We have found that adult rodents exposed for several days/weeks to hypoxia, with an arterial oxygen tension similar to that of chronically hypoxemic patients, manifest a partially irreversible structural disarrangement of the subventricular neurogenic niche (subventricular zone) characterized by displacement of neurons and myelinated axons, flattening of the ependymal cell layer, and thinning of capillary walls. Despite these abnormalities, the number of neuronal and oligodendrocyte progenitors, neuroblasts, and neurosphere-forming cells as well as the proliferative activity in subventricular zone was unchanged. These results suggest that neural stem cells and their undifferentiated progeny are resistant to hypoxia. However, in vivo and in vitro experiments indicate that severe chronic hypoxia decreases the survival of newly generated neurons and oligodendrocytes, with damage of myelin sheaths. These findings help explain the effects of hypoxia on adult neurogenesis and provide new perspectives on brain responsiveness to persistent hypoxemia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.