Evidence map›Paper›PMID 27774460›Full record

ArticleJournal of immunology research2016

Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis.

Ying Wang, Lili Wang, Haoyu Yang, Weichang Yuan, Jingyi Ren, Yanping Bai

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. The Immunology of Psoriasis-Current Concepts in Pathogenesis.Clinical reviews in allergy & immunology · 2024
    Review
  5. Article
  6. Article
  7. Where do T cell subsets stand in SARS-CoV-2 infection: an update.Frontiers in cellular and infection microbiology · 2022
    Review
  8. Review
  9. Article
  10. The Role of Helper T Cells in Psoriasis.Frontiers in immunology · 2021
    Review
  11. Article
  12. Review
  13. Suppressed Programmed Death 1 Expression on CD4Mediators of inflammation · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ying WangClinical Institute of China-Japan Friendship Hospital, Graduate School of Peking Union Medical College, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China; Department of Dermatology & Venerology, China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China.
Lili WangClinical Institute of China-Japan Friendship Hospital, Graduate School of Peking Union Medical College, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China; Department of Dermatology & Venerology, China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China.ORCID 0000-0003-2073-4952
Haoyu YangBeijing University of Chinese Medicine, No. 11, Bei San Huan East Road, Chaoyang District, Beijing 100029, China.
Weichang YuanBeijing University of Chinese Medicine, No. 11, Bei San Huan East Road, Chaoyang District, Beijing 100029, China.
Jingyi RenDepartment of Orthopedics, Taian Chinese Medicine Hospital, No. 58, Dongyue Street, Taishan District, Taian 271000, China.
Yanping BaiClinical Institute of China-Japan Friendship Hospital, Graduate School of Peking Union Medical College, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China; Department of Dermatology & Venerology, China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China.ORCID 0000-0003-3365-4409
Chinese Academy of Medical Sciences & Peking Union Medical College · CNBeijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of cTfh cells were compared between patients with psoriasis vulgaris and healthy controls, and the infiltration of Tfh cells was detected between lesional and nonlesional skin tissues of psoriasis patients. Moreover, the dynamic change of cTfh cells before and after acitretin treatment was evaluated. Our results showed both increased frequency and activation (indicated by higher expression of ICOS, PD-1, HLA-DR, and Ki-67 and increased production of IL-21, IL-17, and IFN-

Indexed as

AdultBiomarkersCase-Control StudiesCytokinesFemaleFlow CytometryHumansImmunohistochemistryImmunophenotypingLymphocyte ActivationLymphocyte CountMaleMiddle AgedPrognosisPsoriasisSeverity of Illness IndexBiomarkersCytokines

Identifiers

PMID27774460
PMCPMC5059604
OpenAlexW2523758861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.