Evidence map›Paper›PMID 27774388›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2016

A Nanosystem Capable of Releasing a Photosensitizer Bioprecursor under Two-Photon Irradiation for Photodynamic Therapy.

Hao Wu, Fang Zeng, Hang Zhang, Jiangsheng Xu, Jianrong Qiu, Shuizhu Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  3. Review
  4. Article
  5. The evolution of clinical guidelines for antimicrobial photodynamic therapy of skin.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hao WuCollege of Materials Science and Engineering State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 P.R. China.
Fang ZengCollege of Materials Science and Engineering State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 P.R. China.
Hang ZhangInstitute of Optical Communication Materials State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 P.R. China.
Jiangsheng XuCollege of Materials Science and Engineering State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 P.R. China.
Jianrong QiuInstitute of Optical Communication Materials State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 P.R. China.
Shuizhu WuCollege of Materials Science and Engineering State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 P.R. China.
South China University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The applications of photodynamic therapy (PDT) are usually limited by photosensitizers' side effects and singlet oxygen's short half-life. Herein, a mitochondria-targeted nanosystem is demonstrated to enhance the PDT efficacy by releasing a bio-precursor of photosensitizer under two-photon irradiation. A phototriggerable coumarin derivative is first synthesized by linking 5-aminolevulinic acid (5-ALA, the bio-precursor) to coumarin; and the nanosystem (CD-ALA-TPP) is then fabricated by covalently incorporating this coumarin derivative and a mitochondria-targeting compound triphenylphosphonium (TPP) onto carbon dots (CDs). Upon cellular internalization, the nanosystem preferentially accumulates in mitochondria; and under one- or two-photon irradiation, it releases 5-ALA molecules that are then metabolized into protoporphyrin IX in mitochondria through a series of biosynthesis processes. The subsequent red light irradiation induces this endogenously synthesized photosensitizer to generate singlet oxygen, thereby causing oxidant damage to mitochondria and then the apoptosis of the cells. Analysis via 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assays indicate that the novel PDT system exhibits enhanced cytotoxicity toward cancer cells. This study may offer a new strategy for designing PDT systems with high efficacy and low side effects.

Indexed as

5‐aminolevulinic acidmitochondrial‐targetedphotocontrolled prodrugphotodynamic therapytwo‐photon absorption

Identifiers

PMID27774388
PMCPMC5063179
OpenAlexW2175379937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.