ArticleJournal of blood transfusion2016
A New Proof of Concept in Bacterial Reduction: Antimicrobial Action of Violet-Blue Light (405 nm) in
Article in Journal of blood transfusion, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Violet photobiomodulation: biological effects and health implications.Lasers in medical science · 2025Pooled it
- Light Photo Treatment at 405 nm Can Effectively KillMicroorganisms · 2026Article
- Photodynamic inactivation of Mycobacterium tuberculosis by broad-spectrum visible light.Applied microbiology and biotechnology · 2026Article
- 405 nm light microbicidal efficacy on Treponema pallidum spiked in ex vivo human platelets.Scientific reports · 2025Article
- 405 nm violet-blue light inactivates hepatitis C cell culture virus (HCVcc) in ex vivo human platelet concentrates and plasma.Scientific reports · 2024Article
- Microbial reduction of prebagged human plasma using 405 nm light and its effects on coagulation factors.AMB Express · 2024Article
- Enhanced antimicrobial efficacy and energy efficiency of low irradiance 405-nm light for bacterial decontamination.Archives of microbiology · 2024Article
- The Involvement of Photobiology in Contemporary Dentistry-A Narrative Review.International journal of molecular sciences · 2023Review
- Visible 405 nm Violet-Blue Light Successfully Inactivates HIV-1 in Human Plasma.Pathogens (Basel, Switzerland) · 2022Article
- Understanding building-occupant-microbiome interactions toward healthy built environments: A review.Frontiers of environmental science & engineering · 2021Review
- Building upon current knowledge and techniques of indoor microbiology to construct the next era of theory into microorganisms, health, and the built environment.Journal of exposure science & environmental epidemiology · 2020Review
- Complete Inactivation of Blood Borne PathogenFrontiers in medicine · 2020Article
- Antimicrobial blue light for decontamination of platelets during storage.Journal of biophotonics · 2020Article
- Proceedings of the Food and Drug Administration public workshop on pathogen reduction technologies for blood safety 2018 (Commentary, p. 3026).Transfusion · 2019Article
- Safety Evaluation of a 405-nm LED Device for Direct Antimicrobial Treatment of the Murine Brain.Comparative medicine · 2019Article
- Can light-based approaches overcome antimicrobial resistance?Drug development research · 2019Review
- Non-ionizing 405 nm Light as a Potential Bactericidal Technology for Platelet Safety: Evaluation ofFrontiers in medicine · 2019Article
- Oxygen-dependent laser inactivation of murine norovirus using visible light lasers.Virology journal · 2018Article
- Antimicrobial blue light inactivation of pathogenic microbes: State of the art.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial contamination of injectable stored biological fluids such as blood plasma and platelet concentrates preserved in plasma at room temperature is a major health risk. Current pathogen reduction technologies (PRT) rely on the use of chemicals and/or ultraviolet light, which affects product quality and can be associated with adverse events in recipients. 405 nm violet-blue light is antibacterial without the use of photosensitizers and can be applied at levels safe for human exposure, making it of potential interest for decontamination of biological fluids such as plasma. As a pilot study to test whether 405 nm light is capable of inactivating bacteria in biological fluids, rabbit plasma and human plasma were seeded with bacteria and treated with a 405 nm light emitting diode (LED) exposure system (patent pending). Inactivation was achieved in all tested samples, ranging from low volumes to prebagged plasma. 99.9% reduction of low density bacterial populations (≤10
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.