ArticleESC heart failure2016
Microcurrent stimulation promotes reverse remodelling in cardiomyocytes.
Article in ESC heart failure, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Association between functional Status and cardiac function in chronic heart failure: insights from the C-MIC II Trial.ESC heart failure · 2026Trial
- Cardio-microcurrent device treatment for heart failure with reduced ejection fraction: Results from the C-MIC II open-label randomized controlled trial.European journal of heart failure · 2025Trial
- Comparison of microcurrent and low level laser therapy on matrix metalloproteinases and tissue inhibitors of metalloproteinases expressions in surgical wound healing.Scientific reports · 2025Trial
- Cardiac microcurrent therapy in heart failure: Mechanistic rationale, early clinical evidence, and future directions.Heart failure reviews · 2026Review
- Two-year outcomes of a cardiac microcurrent device in chronic heart failure: A first-in-human pilot study.ESC heart failure · 2025Article
- Heterogeneous and Composite Bioinks for 3D-Bioprinting of Complex Tissue.Biomedical materials & devices (New York, N.Y.) · 2025Review
- Microcurrent wave alleviates mouse intracranial arterial dolichoectasia development.Scientific reports · 2024Article
- Microcurrent-Mediated Modulation of Myofibroblasts for Cardiac Repair and Regeneration.International journal of molecular sciences · 2024Article
- Molecular Biological Verification of the Healing Effect of Biphasic Microcurrent Electrical Stimulation in Model Rats of Skin Abrasion.Dermatology research and practice · 2024Article
- Electrospun Silk Fibroin-CNT Composite Fibers: Characterization and Application in Mediating Fibroblast Stimulation.Polymers · 2022Article
- Stem Cell Differentiation into Cardiomyocytes: Current Methods and Emerging Approaches.Stem cell reviews and reports · 2022Review
- Device Therapy in Chronic Heart Failure: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2021Review
- Silk-CNT Mediated Fibroblast Stimulation toward Chronic Wound Repair.Recent progress in materials · 2019Article
- Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering.Biomaterials research · 2019Review
- Bioelectrical signals improve cardiac function and modify gene expression of extracellular matrix components.ESC heart failure · 2017Article
- Microcurrent stimulation promotes reverse remodelling in cardiomyocytes.ESC heart failure · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsIt has been shown that electrical stimulation can improve tissue repair in patients. Imbalances in the extracellular matrix composition induce manifestation of heart failure. Here we investigated the application of microcurrent (MC) to modulate the expression of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in cardiomyocytes
methodsCardiomyocytes from young SHR (7 months) and old SHR (14 months) were stimulated
resultsModulation of cardiomyocytes with MC enhances proliferation with no morphological changes
conclusionsOur data indicate that treatment of MC can modulate the expression of MMPs and TIMPs
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.