ArticleESC heart failure2016
The clinical significance of plasma neopterin in heart failure with preserved left ventricular ejection fraction.
Article in ESC heart failure, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Neopterin as a Potential Biomarker for the Early Diagnosis of Heart Failure: A Systematic Review and Meta-analysis.Current medicinal chemistry · 2025Pooled it
- CTRP9 ameliorates heart failure with preserved ejection fraction by regulating lipid metabolism.Journal of translational medicine · 2026Article
- Enhanced expression of neopterin in valve tissue of bicuspid aortic stenosis.Journal of thoracic disease · 2024Article
- Biomarkers in Pulmonary Arterial Hypertension.Diagnostics (Basel, Switzerland) · 2022Review
- Role of neopterin as an inflammatory biomarker in congestive heart failure with insights on effect of drug therapies on its level.Inflammopharmacology · 2022Review
- Circulating Blood-Based Biomarkers in Pulmonary Hypertension.Journal of clinical medicine · 2022Review
- The roles of epicardial adipose tissue in heart failure.Heart failure reviews · 2022Review
- Rationale for the Use of Pirfenidone in Heart Failure With Preserved Ejection Fraction.Frontiers in cardiovascular medicine · 2021Review
- HESC heart failure · 2020Article
- Neopterin is Associated with Disease Severity and Outcome in Patients with Non-Ischaemic Heart Failure.Journal of clinical medicine · 2019Article
- Biochemical Analysis of Three Biological Fluids and its Response to Non-Surgical Periodontal Therapy in Pre and Postmenopausal Women with Periodontitis.Journal of menopausal medicine · 2019Article
- Open access efforts begin to bloom: ESC Heart Failure gets full attention and first impact factor.ESC heart failure · 2019Review
- Clinical significance of serum magnesium levels in patients with heart failure with preserved ejection fraction.Medicine · 2019Observational
- Association between suPAR and cardiac diastolic dysfunction among patients with preserved ejection fraction.Heart and vessels · 2017Article
- Novel Biomarkers for the Risk Stratification of Heart Failure with Preserved Ejection Fraction.Current heart failure reports · 2017Review
- Relationship between Oxidative Stress, Physical Activity, and Vitamin Intake in Patients with Asthma.Yonago acta medica · 2017Article
- The clinical significance of plasma neopterin in heart failure with preserved left ventricular ejection fraction.ESC heart failure · 2016Article
- Estimation of neopterin as a biomarker in biofluids of pre and post-menopausal women after initial periodontal therapy: A biochemical assay.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAlthough inflammation plays an important role in the pathogenesis of heart failure (HF), the precise pathophysiological role of inflammation in HF with preserved left ventricular ejection fraction (HFpEF) still remains unclear. Hence, we examined the clinical significance of plasma neopterin, an inflammatory biomarker, in HFpEF patients. METHODS AND
resultsIn the present study, we recruited consecutive HFpEF patients hospitalized in Kumamoto University Hospital, and further measured plasma neopterin by high-performance liquid chromatography and serum derivatives of reactive oxidative metabolites (DROM), a new biomarker of reactive oxygen species. Compared with risk factors (number of patients, age, sex, and equal incidence of diabetes mellitus, hypertension, and dyslipidemia) -matched non-HF patients (
conclusionsPlasma neopterin levels significantly increased in HFpEF and correlated with the severity of HF. Furthermore, high neopterin were significantly correlated with future cardiovascular events, indicating that measurement of plasma neopterin might provide clinical benefits for risk stratification of HFpEF patients. © 2015 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.
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