Evidence map›Paper›PMID 27774140›Full record

ArticleMedChemComm2016

Open PHACTS computational protocols for

D Digles, B Zdrazil, J-M Neefs, H Van Vlijmen, C Herhaus, A Caracoti, J Brea, B Roibás, M I Loza, N Queralt-Rosinach and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
8.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. YummyData: providing high-quality open life science data.Database : the journal of biological databases and curation · 2018
    Article
  5. Article
  6. Review
  7. Empowering pharmacoinformatics by linked life science data.Journal of computer-aided molecular design · 2017
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 14 countries.

D DiglesDepartment of Pharmaceutical Chemistry , University of Vienna , Pharmacoinformatics Research Group , Althanstraße 14 , 1090 Wien , Austria . Email: daniela.digles@univie.ac.at.
B ZdrazilDepartment of Pharmaceutical Chemistry , University of Vienna , Pharmacoinformatics Research Group , Althanstraße 14 , 1090 Wien , Austria . Email: daniela.digles@univie.ac.at.
J-M NeefsJanssen Research & Development , Turnhoutseweg 30 , B-2340 Beerse , Belgium . Email: ejacoby@its.jnj.com.
H Van VlijmenJanssen Research & Development , Turnhoutseweg 30 , B-2340 Beerse , Belgium . Email: ejacoby@its.jnj.com.
C HerhausMerck KGaA, Merck Serono R&D , Computational Chemistry , Frankfurter Straße 250 , 64293 Darmstadt , Germany.
A CaracotiBIOVIA , a Dassault Systèmes brand , 334 Cambridge Science Park , Cambridge CB4 0WN , UK.
J BreaGrupo BioFarma-USEF , Departamento de Farmacología , Facultad de Farmacia , Campus Universitario Sur s/n , 15782 Santiago de Compostela , Spain.
B RoibásGrupo BioFarma-USEF , Departamento de Farmacología , Facultad de Farmacia , Campus Universitario Sur s/n , 15782 Santiago de Compostela , Spain.
M I LozaGrupo BioFarma-USEF , Departamento de Farmacología , Facultad de Farmacia , Campus Universitario Sur s/n , 15782 Santiago de Compostela , Spain.
N Queralt-RosinachResearch Programme on Biomedical Informatics (GRIB) , Hospital del Mar Medical Research Institute (IMIM) , Department of Experimental and Health Sciences , Universitat Pompeu Fabra , C/Dr Aiguader 88 , E-08003 Barcelona , Spain.
L I FurlongResearch Programme on Biomedical Informatics (GRIB) , Hospital del Mar Medical Research Institute (IMIM) , Department of Experimental and Health Sciences , Universitat Pompeu Fabra , C/Dr Aiguader 88 , E-08003 Barcelona , Spain.
A GaultonEuropean Molecular Biology Laboratory , European Bioinformatics Institute (EMBL-EBI) , Wellcome Genome Campus , Hinxton , Cambridge CB10 1SD , UK.
L BartekGlaxoSmithKline , Medicines Research Centre , Stevenage SG1 2NY , UK.
S SengerGlaxoSmithKline , Medicines Research Centre , Stevenage SG1 2NY , UK.
C ChichesterSwiss Institute of Bioinformatics , CALIPHO Group , CMU Rue Michel-Servet 1 , 1211 Geneva 4 , Switzerland ; Nestlé Institute of Health Sciences SA , EPFL Innovation Park, Bâtiment H , 1015 Lausanne , Switzerland.
O EngkvistChemistry Innovation Centre , Discovery Sciences , AstraZeneca R&D Gothenburg , SE-431 83 Mölndal , Sweden.
C T EveloDepartment of Bioinformatics - BiGCaT , P.O. Box 616 , UNS50 Box19 , NL-6200MD Maastricht , The Netherlands.
N I FranklinOpen Innovation Drug Discovery , Discovery Chemistry Eli Lilly and Company , Lilly Corporate Center , DC 1920 , Indianapolis , IN 46285 , USA.
D MarrenEli Lilly and Company Ltd. , Lilly Research Centre , Erl Wood Manor, Sunninghill Road , Windlesham , Surrey GU20 6PH , England , UK.
G F EckerDepartment of Pharmaceutical Chemistry , University of Vienna , Pharmacoinformatics Research Group , Althanstraße 14 , 1090 Wien , Austria . Email: daniela.digles@univie.ac.at.
E JacobyJanssen Research & Development , Turnhoutseweg 30 , B-2340 Beerse , Belgium . Email: ejacoby@its.jnj.com.
Janssen (Belgium) · BEUniversidade de Santiago de Compostela · ESUniversity of Vienna · ATEli Lilly (United States) · USGlaxoSmithKline (United Kingdom) · GBUniversitat Pompeu Fabra · ESDassault Systèmes (France) · FREuropean Bioinformatics Institute · GBLaerdal (Norway) · NOSIB Swiss Institute of Bioinformatics · CHTechnische Universität Darmstadt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phenotypic screening is in a renaissance phase and is expected by many academic and industry leaders to accelerate the discovery of new drugs for new biology. Given that phenotypic screening is per definition target agnostic, the emphasis of

Identifiers

PMID27774140
PMCPMC5063042
OpenAlexW2364148038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.