Evidence map›Paper›PMID 27774006›Full record

ReviewPragmatic and observational research2010

Biological correlates of migraine and cluster headaches: an overview of their potential use in diagnosis and treatment.

Aron D Mosnaim, Javier Puente, Marion E Wolf

Abstract readReview
In one paragraph

Review in Pragmatic and observational research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aron D MosnaimDepartment of Cellular and Molecular Pharmacology, Rosalind Franklin University, Chicago Medical School, Chicago, IL, USA.
Javier PuenteDepartment of Cellular and Molecular Pharmacology, Rosalind Franklin University, Chicago Medical School, Chicago, IL, USA; Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile.
Marion E WolfInternational Neuropsychiatry Consultants, Highland Park, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current diagnostic criteria for headaches are based on the International Classification for Headache Disorders, second edition, which is largely built on data obtained from clinical examinations and patients' medical histories. Despite decades of vigorous basic and clinical research, we still lack reliable clinical laboratory diagnostic markers for headaches, which clearly obstructs the physician's ability to optimize and follow the patient's response to treatment protocols as well as holds back the discovery and implementation of new therapeutic modalities. In this paper, we review and discuss current efforts to identify and characterize biochemical and immunological changes in biological fluids and tissue that may be specifically associated with the etiology and/or pathophysiology of migraine and cluster headaches; we also discuss some of the recent genetic findings and ion channel modulation studies that may help to distinguish among various headache populations.

Indexed as

biochemicalenkephalin aminopeptidaseenkephalin degradation kineticsgenetic alterationsimmunologicalpain

Identifiers

PMID27774006
PMCPMC5044998

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.