Evidence map›Paper›PMID 27773989›Full record

ArticleEnvironmental health insights2016

Residual Isocyanates in Medical Devices and Products: A Qualitative and Quantitative Assessment.

Gillian Franklin, Homero Harari, Samavi Ahsan, Dhimiter Bello, David A Sterling, Jonathan Nedrelow, Scott Raynaud, Swati Biswas, Youcheng Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health insights, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Gillian FranklinDepartment of Environmental and Occupational Health Sciences, University of North Texas Health Science Center, Fort Worth, TX, USA.; Current Affiliation: Postdoctoral Research Fellow, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Homero HarariDepartment of Work Environment, University of Massachusetts at Lowell, Lowell, MA, USA.; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Samavi AhsanDepartment of Environmental and Occupational Health Sciences, University of North Texas Health Science Center, Fort Worth, TX, USA.; CACI International Inc., Arlington, VA, USA.
Dhimiter BelloDepartment of Work Environment, University of Massachusetts at Lowell, Lowell, MA, USA.
David A SterlingDepartment of Environmental and Occupational Health Sciences, University of North Texas Health Science Center, Fort Worth, TX, USA.
Jonathan NedrelowNeonatal Intensive Care Unit, Cook Children's Hospital, Fort Worth, TX, USA.
Scott RaynaudResearch Administration, Cook Children's Hospital, Fort Worth, TX, USA.
Swati BiswasDepartment of Mathematical Sciences, University of Texas at Dallas, Richardson, TX, USA.
Youcheng LiuDepartment of Environmental and Occupational Health Sciences, University of North Texas Health Science Center, Fort Worth, TX, USA.
University of North Texas Health Science Center · USIcahn School of Medicine at Mount Sinai · USThe University of Texas at Dallas · USUniversity of North Texas · US

Funding

Isocyanate Skin and Air Exposure: Assessment and ControlR01OH009375 · OH · YALE UNIVERSITY · PI REDLICH, CARRIE A · 2009 to 2012
$1.6M
Evaluation of Protective Clothing to Prevent Diisocyanate Exposures in the CollisR01OH009364 · OH · UNIVERSITY OF WASHINGTON · PI YOST, MICHAEL G · 2009 to 2011
$1.2M
NIOSH CDC HHS R01 OH009364NIOSH CDC HHS R01 OH009375
6 · The paper itself

Abstract

We conducted a pilot qualitative and quantitative assessment of residual isocyanates and their potential initial exposures in neonates, as little is known about their contact effect. After a neonatal intensive care unit (NICU) stockroom inventory, polyurethane (PU) and PU foam (PUF) devices and products were qualitatively evaluated for residual isocyanates using Surface SWYPE™. Those containing isocyanates were quantitatively tested for methylene diphenyl diisocyanate (MDI) species, using UPLC-UV-MS/MS method. Ten of 37 products and devices tested, indicated both free and bound residual surface isocyanates; PU/PUF pieces contained aromatic isocyanates; one product contained aliphatic isocyanates. Overall, quantified mean MDI concentrations were low (4,4'-MDI = 0.52 to 140.1 pg/mg) and (2,4'-MDI = 0.01 to 4.48 pg/mg). The 4,4'-MDI species had the highest measured concentration (280 pg/mg). Commonly used medical devices/products contain low, but measurable concentrations of residual isocyanates. Quantifying other isocyanate species and neonatal skin exposure to isocyanates from these devices and products requires further investigation.

Indexed as

asthmaisocyanatesmedical devices and productsmethylene diphenyl diisocyanateneonatal exposureskin sensitization

Identifiers

PMID27773989
PMCPMC5067089
OpenAlexW2530835355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.