Evidence map›Paper›PMID 27773967›Full record

ArticleSensors and actuators. B, Chemical2016

Ultrasonic Transducer-Guided Electrochemical Impedance Spectroscopy to Assess Lipid-Laden Plaques.

Jianguo Ma, Yuan Luo, René R Sevag Packard, Teng Ma, Yichen Ding, Parinaz Abiri, Yu-Chong Tai, Qifa Zhou, Kirk K Shung, Rongsong Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors and actuators. B, Chemical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jianguo MaDepartment of Bioengineering, School of Engineering and Applied Sciences, University of California, Los Angeles, CA 90095, USA; Division of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, CA 90095, USA.
Yuan LuoDepartment of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
René R Sevag PackardDepartment of Bioengineering, School of Engineering and Applied Sciences, University of California, Los Angeles, CA 90095, USA; Division of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, CA 90095, USA.
Teng MaDepartment of Biomedical Engineering and Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Yichen DingDepartment of Bioengineering, School of Engineering and Applied Sciences, University of California, Los Angeles, CA 90095, USA; Division of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, CA 90095, USA.
Parinaz AbiriDepartment of Bioengineering, School of Engineering and Applied Sciences, University of California, Los Angeles, CA 90095, USA; Division of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, CA 90095, USA.
Yu-Chong TaiDepartment of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Qifa ZhouDepartment of Biomedical Engineering and Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Kirk K ShungDepartment of Biomedical Engineering and Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Rongsong LiDepartment of Bioengineering, School of Engineering and Applied Sciences, University of California, Los Angeles, CA 90095, USA; Division of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, CA 90095, USA.
Tzung HsiaiDepartment of Bioengineering, School of Engineering and Applied Sciences, University of California, Los Angeles, CA 90095, USA; Division of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, CA 90095, USA; Department of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
A Resource on Medical Ultrasonic Transducer TechnologyP41EB002182 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHUNG, K KIRK · 2003 to 2016
$13.3M
The Los Angeles PRISMS Center: The Biomedical REAl-Time Health Evaluation (BREATHE) PlatformU54EB022002 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUI, ALEX · 2015 to 2016
$6.1M
Linking Spatial Variations Shear Stress-Oxidative StressR01HL083015 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K · 2006 to 2015
$3.9M
Shear Stress and Light-Sheets to Study Cardiac TrabeculationR01HL129727 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2015 to 2024
$3.5M
Electronica Impedance to Access Metabolically Active PlaqueR01HL118650 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K · 2014 to 2022
$3.3M
Micro-Sensors to Study Electrical and Mechanical Coupling of Injured MyocardiumR01HL111437 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K, XU, XIAOLEI · 2012 to 2020
$3.1M
NHLBI NIH HHS R01 HL083015NHLBI NIH HHS R01 HL111437NHLBI NIH HHS R01 HL118650NHLBI NIH HHS R01 HL129727NIBIB NIH HHS P41 EB002182NIBIB NIH HHS U54 EB022002NIGMS NIH HHS T32 GM008042
6 · The paper itself

Abstract

Plaque rupture causes acute coronary syndromes and stroke. Intraplaque oxidized low density lipoprotein (oxLDL) is metabolically unstable and prone to induce rupture. We designed an intravascular ultrasound (IVUS)-guided electrochemical impedance spectroscopy (EIS) sensor to enhance the detection reproducibility of oxLDL-laden plaques. The flexible 2-point micro-electrode array for EIS was affixed to an inflatable balloon anchored onto a co-axial double layer catheter (outer diameter = 2 mm). The mechanically scanning-driven IVUS transducer (45 MHz) was deployed through the inner catheter (diameter = 1.3 mm) to the acoustic impedance matched-imaging window. Water filled the inner catheter to match acoustic impedance and air was pumped between the inner and outer catheters to inflate the balloon. The integrated EIS and IVUS sensor was deployed into the ex vivo aortas dissected from the fat-fed New Zealand White (NZW) rabbits (n=3 for fat-fed, n= 5 normal diet). IVUS imaging was able to guide the 2-point electrode to align with the plaque for EIS measurement upon balloon inflation. IVUS-guided EIS signal demonstrated reduced variability and increased reproducibility (

Indexed as

Dual sensor-based intravascular catheterElectrochemical Impedance SpectroscopyFlexible 2-point electrodePlaque assessmentUltrasonic transducers

Identifiers

PMID27773967
PMCPMC5068578

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.