Evidence map›Paper›PMID 27773930›Full record

Trial reportLeukemia2017

Non-coding NOTCH1 mutations in chronic lymphocytic leukemia; their clinical impact in the UK CLL4 trial.

M Larrayoz, M J J Rose-Zerilli, L Kadalayil, H Parker, S Blakemore, J Forster, Z Davis, A J Steele, A Collins, M Else and 3 more

Open access · hybridAbstract readClinical TrialLetter
In one paragraph

Trial report in Leukemia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

M LarrayozCaner Genomics, Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
M J J Rose-ZerilliCaner Genomics, Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
L KadalayilGenetic Epidemiology and Bioinformatics, Faculty of Medicine, University of Southampton, Southampton, UK.
H ParkerCaner Genomics, Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
S BlakemoreCaner Genomics, Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0003-2892-1162
J ForsterCaner Genomics, Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Z DavisDepartment of Molecular Pathology, Royal Bournemouth Hospital, Bournemouth, UK.
A J SteeleCaner Genomics, Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
A CollinsGenetic Epidemiology and Bioinformatics, Faculty of Medicine, University of Southampton, Southampton, UK.
M ElseDivision of Molecular Pathology, The Institute of Cancer Research, London, UK.
D CatovskyDivision of Molecular Pathology, The Institute of Cancer Research, London, UK.
D G OscierDepartment of Molecular Pathology, Royal Bournemouth Hospital, Bournemouth, UK.
J C StreffordCaner Genomics, Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Genomics (United Kingdom) · GBInstitute of Cancer Research · GBRoyal Bournemouth Hospital · GBUniversity of Southampton · GB

Funding

Cancer Research UK A15581Cancer Research UK A18087
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MutationHumansLeukemia, Lymphocytic, Chronic, B-CellPrognosisReceptor, Notch1Survival AnalysisNOTCH1 protein, humanReceptor, Notch1

Identifiers

PMID27773930
PMCPMC5289571
OpenAlexW2533368262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.