ReviewNature reviews. Genetics2016
The state of play in higher eukaryote gene annotation.
Review in Nature reviews. Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
125 citing papers in PubMed, 133 citations in OpenAlex.
- Targeted ortholog search in unannotated genome assemblies with fDOG-Assembly.Nucleic acids research · 2026Article
- Gene model for the ortholog ofbioRxiv : the preprint server for biology · 2026Article
- Gene model for the ortholog ofbioRxiv : the preprint server for biology · 2026Article
- Gene model for the ortholog ofbioRxiv : the preprint server for biology · 2026Article
- Gene model for the ortholog ofbioRxiv : the preprint server for biology · 2026Article
- Gene model for the ortholog ofbioRxiv : the preprint server for biology · 2026Article
- Gene model for the ortholog ofbioRxiv : the preprint server for biology · 2026Article
- Gene model for the ortholog ofbioRxiv : the preprint server for biology · 2026Article
- Gene model for the ortholog ofbioRxiv : the preprint server for biology · 2026Article
- Gene model for the ortholog ofbioRxiv : the preprint server for biology · 2026Article
- From structural pangenomes to functional panomics in plants.Molecular biology and evolution · 2026Review
- GeneExt: a gene model extension tool for enhanced single-cell RNA-seq analysis.Bioinformatics (Oxford, England) · 2026Article
- Gene model for the ortholog ofbioRxiv : the preprint server for biology · 2026Article
- Improved reconstruction of transcripts and coding sequences from RNA-seq data.Nucleic acids research · 2026Article
- Gene model for the ortholog ofbioRxiv : the preprint server for biology · 2026Article
- Gene model for the ortholog ofmicroPublication biology · 2026Article
- Gene model for the ortholog ofmicroPublication biology · 2026Article
- Phase-dependent reorganization of circulating miRNA networks following short maximal exercise.Frontiers in physiology · 2026Article
- Gene model for the ortholog ofmicroPublication biology · 2026Article
- Gene model for the ortholog ofmicroPublication biology · 2026Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A genome sequence is worthless if it cannot be deciphered; therefore, efforts to describe - or 'annotate' - genes began as soon as DNA sequences became available. Whereas early work focused on individual protein-coding genes, the modern genomic ocean is a complex maelstrom of alternative splicing, non-coding transcription and pseudogenes. Scientists - from clinicians to evolutionary biologists - need to navigate these waters, and this has led to the design of high-throughput, computationally driven annotation projects. The catalogues that are being produced are key resources for genome exploration, especially as they become integrated with expression, epigenomic and variation data sets. Their creation, however, remains challenging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.