Evidence map›Paper›PMID 27773678›Full record

ArticleBiological psychology2016

Heart rate variability: Pre-deployment predictor of post-deployment PTSD symptoms.

Jeffrey M Pyne, Joseph I Constans, Mark D Wiederhold, Douglas P Gibson, Timothy Kimbrell, Teresa L Kramer, Jeffery A Pitcock, Xiaotong Han, D Keith Williams, Don Chartrand and 5 more

3 registry-linked trialsAbstract read
In one paragraph

Article in Biological psychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03777267 narecruitingnot on this mapstarted 2019, after this paper: background citation

Cereset Research Exploratory Study

TypeinterventionalSponsorWake Forest University Health SciencesRan2019 to 2028Enrolled200ConditionsNeurological Diseases or Conditions, Cardiovascular Conditions After Birth, Psychophysiologic DisordersArmsActive CR
NCT04682197 nacompletednot on this mapstarted 2021, after this paper: background citation

Cereset Research To Reduce Stress In Healthcare Workers In The Time Of COVID-19

TypeinterventionalSponsorWake Forest University Health SciencesRan2021 to 2023Enrolled144ConditionsHealth Personnel, Stress, Anxiety, InsomniaArmsCereset Research
NCT05229107 nawithdrawnnot on this mapstarted 2024, after this paper: background citation

Randomized Controlled Pilot Trial of Cereset Research For Chronic Nausea

TypeinterventionalSponsorWake Forest University Health SciencesRan2024 to 2024Enrolled0ConditionsNausea, Gastroparesis, Stress, AnxietyArmsCereset Research
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Article
  7. Review
  8. Article
  9. Article
  10. Heart Rate Variability in Psychiatric Disorders: A Systematic Review.Neuropsychiatric disease and treatment · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jeffrey M PyneCenter for Mental Health Outcomes Research, Central Arkansas Veterans Healthcare System, North Little Rock, AR, 72114, United States; South Central Mental Illness Education and Clinical Center, Central Arkansas Veterans Healthcare System, North Little Rock, AR, 72114, United States; Division of Health Services Research, Department of Psychiatry, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States. Electronic address: jmpyne@uams.edu.
Joseph I ConstansSouth Central Mental Illness Education and Clinical Center, Central Arkansas Veterans Healthcare System, North Little Rock, AR, 72114, United States; Southeastern Louisiana Veterans Health Care System (629/11F), PO Box 61011, New Orleans, LA 70161, United States, United States; Tulane University, New Orleans, LA, United States.
Mark D WiederholdVirtual Reality Medical Centers, 9565 Waples Street, Suite 200, San Diego, CA 92121, United States.
Douglas P GibsonOffice of the State Surgeon, Virginia Army National Guard, BLDG 1310, Ft. Pickett, Blackstone VA, 23824, United States.
Timothy KimbrellCenter for Mental Health Outcomes Research, Central Arkansas Veterans Healthcare System, North Little Rock, AR, 72114, United States; South Central Mental Illness Education and Clinical Center, Central Arkansas Veterans Healthcare System, North Little Rock, AR, 72114, United States.
Teresa L KramerDivision of Health Services Research, Department of Psychiatry, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States.
Jeffery A PitcockCenter for Mental Health Outcomes Research, Central Arkansas Veterans Healthcare System, North Little Rock, AR, 72114, United States.
Xiaotong HanCenter for Mental Health Outcomes Research, Central Arkansas Veterans Healthcare System, North Little Rock, AR, 72114, United States; South Central Mental Illness Education and Clinical Center, Central Arkansas Veterans Healthcare System, North Little Rock, AR, 72114, United States; Division of Health Services Research, Department of Psychiatry, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States.
D Keith WilliamsDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States.
Don ChartrandEase interactive, Inc., San Diego, CA, United States.
Richard N GevirtzAlliant International University, 10455 Pomerado Road, San Diego, CA 92131, United States.
James SpiraNational Center for PTSD, US Department of Veterans Affairs, and Department of Psychiatry, University of Hawaii School of Medicine, Honolulu, HI 96819, United States.
Brenda K WiederholdVirtual Reality Medical Centers, 9565 Waples Street, Suite 200, San Diego, CA 92121, United States.
Rollin McCratyInstitute of HeartMath, 14700 West Park Ave., Boulder Creek, CA 95006, United States.
Thomas R McCuneOffice of the State Surgeon, Virginia Army National Guard, BLDG 1310, Ft. Pickett, Blackstone VA, 23824, United States.

Funding

Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
Center for Translational NeuroscienceP20GM103425 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI GARCIA-RILL, EDGAR E. · 2012 to 2013
$4.1M
Arkansas Center for Clinical Translational ResearchKL2TR000063 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$459k
NCATS NIH HHS KL2 TR000063NCATS NIH HHS UL1 TR000039NIGMS NIH HHS P20 GM103425
6 · The paper itself

Abstract

Heart rate variability is a physiological measure associated with autonomic nervous system activity. This study hypothesized that lower pre-deployment HRV would be associated with higher post-deployment post-traumatic stress disorder (PTSD) symptoms. Three-hundred-forty-three Army National Guard soldiers enrolled in the Warriors Achieving Resilience (WAR) study were analyzed. The primary outcome was PTSD symptom severity using the PTSD Checklist - Military version (PCL) measured at baseline, 3- and 12-month post-deployment. Heart rate variability predictor variables included: high frequency power (HF) and standard deviation of the normal cardiac inter-beat interval (SDNN). Generalized linear mixed models revealed that the pre-deployment PCL*ln(HF) interaction term was significant (p<0.0001). Pre-deployment SDNN was not a significant predictor of post-deployment PCL. Covariates included age, pre-deployment PCL, race/ethnicity, marital status, tobacco use, childhood abuse, pre-deployment traumatic brain injury, and previous combat zone deployment. Pre-deployment heart rate variability predicts post-deployment PTSD symptoms in the context of higher pre-deployment PCL scores.

Indexed as

AdultAutonomic Nervous SystemCombat DisordersFemaleHeart RateHumansIraq War, 2003-2011Linear ModelsLongitudinal StudiesMaleMilitary PersonnelPredictive Value of TestsStress Disorders, Post-TraumaticUnited StatesYoung Adultcombat stressheart rate variabilitylongitudinalmilitaryPost-traumatic stress disorder (PTSD)predictionrisk factors

Identifiers

PMID27773678
PMCPMC5335901

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.