ArticleNeurobiology of learning and memory2016
5-HT2C receptors in the BNST are necessary for the enhancement of fear learning by selective serotonin reuptake inhibitors.
Article in Neurobiology of learning and memory, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Efficacy and safety of selective serotonin reuptake inhibitors for diabetes mellitus with depression: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice.Translational psychiatry · 2026Article
- Causal links between serotonin dynamics and cued fear learning: evidence from experimental studies.Frontiers in computational neuroscience · 2026Review
- Serotonergic modulation of the BNST-CeA pathway reveals sex differences in fear learning.Nature neuroscience · 2025Article
- 5-HTBrain sciences · 2024Article
- The role and mechanism of 5-HTDRN-BNST neural circuit in anxiety and fear lesions.Frontiers in neuroscience · 2024Review
- Chemogenetic activation of the ventral subiculum-BNST pathway reduces context fear expression.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Sex differences in fear responses: Neural circuits.Neuropharmacology · 2023Review
- Constitutive 5-HT2C receptor knock-out facilitates fear extinction through altered activity of a dorsal raphe-bed nucleus of the stria terminalis pathway.Translational psychiatry · 2022Article
- Aversive Contexts Reduce Activity in the Ventral Subiculum- BNST Pathway.Neuroscience · 2022Article
- Exercise reduces the anxiogenic effects of meta-chlorophenylpiperazine: The role of 5-HT2C receptors in the bed nucleus of the stria terminalis.Frontiers in synaptic neuroscience · 2022Article
- Agomelatine for the treatment of generalized anxiety disorder: focus on its distinctive mechanism of action.Therapeutic advances in psychopharmacology · 2022Review
- Role of the Novel Peptide Phoenixin in Stress Response and Possible Interactions with Nesfatin-1.International journal of molecular sciences · 2021Review
- Extended amygdala circuits are differentially activated by context fear conditioning in male and female rats.Neurobiology of learning and memory · 2021Article
- Sex-specific effects of social defeat stress on miRNA expression in the anterior BNST.Behavioural brain research · 2021Article
- Somatostatin Neurons of the Bed Nucleus of Stria Terminalis Enhance Associative Fear Memory Consolidation in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- AgRP neurons trigger long-term potentiation and facilitate food seeking.Translational psychiatry · 2021Article
- Neuronal diversity of the amygdala and the bed nucleus of the stria terminalis.Handbook of behavioral neuroscience · 2020Article
- Sex-Dependent Modulation of Anxiety and Fear by 5-HTACS chemical neuroscience · 2019Article
- Defining circuit-specific roles for G protein-coupled receptors in aversive learning.Current opinion in behavioral sciences · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed to treat anxiety and depression, yet they paradoxically increase anxiety during initial treatment. Acute administration of these drugs prior to learning can also enhance Pavlovian cued fear conditioning. This potentiation has been previously reported to depend upon the bed nucleus of the stria terminalis (BNST). Here, using temporary inactivation, we confirmed that the BNST is not necessary for the acquisition of cued or contextual fear memory. Systemic administration of the SSRI citalopram prior to fear conditioning led to an upregulation of the immediate early gene Arc (activity-regulated cytoskeleton-associated protein) in the oval nucleus of the BNST, and a majority of these neurons expressed the 5-HT2C receptor. Finally, local infusions of a 5-HT2C receptor antagonist directly into the oval nucleus of the BNST prevented the fear memory-enhancing effects of citalopram. These findings highlight the ability of the BNST circuitry to be recruited into gating fear and anxiety-like behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.