ArticleNeuron2016
Fast 3D Imaging of Spine, Dendritic, and Neuronal Assemblies in Behaving Animals.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Methods, Trade-offs, and Opportunities in High-speed Optical Microscopy for Neural Voltage imaging.Nature photonics · 2026Article
- Deep learning-assisted mapping of dendritic spines using sequential 2D two-photon calcium imaging.iScience · 2026Article
- Article
- Cellular multipoint adaptive technology for two-photon mesoscope.Neurophotonics · 2026Article
- A real-time all-optical interface for dynamic perturbation of neural activity during behavior.Cell reports methods · 2025Article
- Moculus: an immersive virtual reality system for mice incorporating stereo vision.Nature methods · 2025Article
- Compact module for video-rate image mosaics in two-photon microscopy.Optics express · 2025Article
- Article
- A Flexible, Implantable, Bioelectronic Electroporation Device for Targeted Ablation of Seizure Foci in the Mouse Brain.Sensors (Basel, Switzerland) · 2024Article
- CRASH2p: Closed-loop Two Photon Imaging in a Freely Moving Animal.bioRxiv : the preprint server for biology · 2024Article
- Brain-wide neural recordings in mice navigating physical spaces enabled by robotic neural recording headstages.Nature methods · 2024Article
- Hippocampal recording with a soft microelectrode array in a cranial window imaging scheme: a validation study.Scientific reports · 2024Article
- Two-photon all-optical neurophysiology for the dissection of larval zebrafish brain functional and effective connectivity.Communications biology · 2024Article
- Neurophotonics beyond the surface: unmasking the brain's complexity exploiting optical scattering.Neurophotonics · 2024Article
- Review
- Neurophotonics beyond the Surface: Unmasking the Brain's Complexity Exploiting Optical Scattering.ArXiv · 2024Article
- Brain-wide neural recordings in mice navigating physical spaces enabled by a cranial exoskeleton.Research square · 2023Article
- Inhibitory control of sharp-wave ripple duration during learning in hippocampal recurrent networks.Nature neuroscience · 2023Article
- Article
- Ten-kilohertz two-photon microscopy imaging of single-cell dendritic activity and hemodynamicsNeurophotonics · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding neural computation requires methods such as 3D acousto-optical (AO) scanning that can simultaneously read out neural activity on both the somatic and dendritic scales. AO point scanning can increase measurement speed and signal-to-noise ratio (SNR) by several orders of magnitude, but high optical resolution requires long point-to-point switching time, which limits imaging capability. Here we present a novel technology, 3D DRIFT AO scanning, which can extend each scanning point to small 3D lines, surfaces, or volume elements for flexible and fast imaging of complex structures simultaneously in multiple locations. Our method was demonstrated by fast 3D recording of over 150 dendritic spines with 3D lines, over 100 somata with squares and cubes, or multiple spiny dendritic segments with surface and volume elements, including in behaving animals. Finally, a 4-fold improvement in total excitation efficiency resulted in about 500 × 500 × 650 μm scanning volume with genetically encoded calcium indicators (GECIs).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.