Evidence map›Paper›PMID 27773355›Full record

ReviewBiological psychiatry2017

Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder.

Helen E Vuong, Elaine Y Hsiao

3 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biological psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 293 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
293citing papers in PubMed, 9 pooled it
22.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03152838 unknown statusnot on this map

The Role of Epigenetic Modifications in Autism Spectrum Disorder Through DNA Methylation

TypeobservationalSponsorAssiut UniversityRan2017 to 2019Enrolled40ConditionsAutism Spectrum DisorderArmsDNA methylation and Real-time Polymerase Chain Reaction Analysis, Gilliam Autism Rating Scale Arabic version
NCT07450443 phase2 / phase3recruitingnot on this mapstarted 2023, after this paper: background citation

Role of the Gut Vascular Barrier and Microbiota in Autism Spectrum Disorders: Evaluation of Efficacy of Postbiotic-based Nutraceutical Treatment

TypeinterventionalSponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaRan2023 to 2027Enrolled90ConditionsAutism, Autism Disorder, Autism Spectrum Disorder (ASD)ArmsPostbiotiX Comfort®, Control
NCT07646808 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Association Between Gut Microbiome Characteristics and Neurodevelopmental Functioning in Children With Autism Spectrum Disorder: A Multidomain Investigation of the Gut-Motor Axis

TypeobservationalSponsorSaveetha UniversityRan2026 to 2026Enrolled600ConditionsAutism Spectrum Disorder
3 · Its place in the literature

Who cites it

293 citing papers in PubMed, 9 syntheses or guidelines pooled it, 575 citations in OpenAlex.

  1. Pooled it
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  8. A Meta-analysis of Gut Microbiota in Children with Autism.Journal of autism and developmental disorders · 2022
    Pooled it
  9. Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review.Frontiers in cellular and infection microbiology · 2022
    Pooled it
  10. Article
  11. Review
  12. Article
  13. Article
  14. A Developmental Neuroimmune Cascade Model of Autism Spectrum Disorder.International journal of molecular sciences · 2026
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

233 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Helen E VuongDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, California.
Elaine Y HsiaoDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, California. Electronic address: ehsiao@ucla.edu.
University of California, Los Angeles · US

Funding

UPLIFT: UCLA Postdocs' Longitudinal Investment in Faculty TrainingK12GM106996 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAREY, MICHAEL F, VILLANUEVA, CLAUDIO J · 2016 to 2025
$7.1M
Uncovering microbial modulators of neuroactive molecules as novel therapeutics.DP5OD017924 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAO, ELAINE · 2013 to 2017
$1.9M
Functional Role of IL-6 in Fetal Brain Development and Abnormal BehaviorF31MH090749 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI HSIAO, ELAINE · 2011 to 2012
$64k
NIGMS NIH HHS K12 GM106996NIH HHS DP5 OD017924NIMH NIH HHS F31 MH090749
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder that affects one in 45 children in the United States, with a similarly striking prevalence in countries around the world. However, mechanisms underlying its etiology and manifestations remain poorly understood. Although ASD is diagnosed based on the presence and severity of impaired social communication and repetitive behavior, immune dysregulation and gastrointestinal issues are common comorbidities. The microbiome is an integral part of human physiology; recent studies show that changes in the gut microbiota can modulate gastrointestinal physiology, immune function, and even behavior. Links between particular bacteria from the indigenous gut microbiota and phenotypes relevant to ASD raise the important question of whether microbial dysbiosis plays a role in the development or presentation of ASD symptoms. Here we review reports of microbial dysbiosis in ASD. We further discuss potential effects of the microbiota on ASD-associated symptoms, drawing on signaling mechanisms for reciprocal interactions among the microbiota, immunity, gut function, and behavior. In addition, we discuss recent findings supporting a role for the microbiome as an interface between environmental and genetic risk factors that are associated with ASD. These studies highlight the integration of pathways across multiple body systems that together can impact brain and behavior and suggest that changes in the microbiome may contribute to symptoms of neurodevelopmental disease.

Indexed as

Gastrointestinal MicrobiomeAdolescentAdultAnimalsAutism Spectrum DisorderBehavior, AnimalBrainChildChild, PreschoolDisease Models, AnimalEndophenotypesGastrointestinal TractHumansMiceRisk FactorsAutismGastrointestinal tractGut-brain axisInflammationMicrobiotaNeurodevelopment

Identifiers

PMID27773355
PMCPMC5285286
OpenAlexW2515537885

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.