Evidence map›Paper›PMID 27771900›Full record

ArticleMolecular neurobiology2017

RhoA/Rho Kinase Mediates Neuronal Death Through Regulating cPLA

Xiangbing Wu, Chandler L Walker, Qingbo Lu, Wei Wu, Daniel B Eddelman, Jonathan M Parish, Xiao-Ming Xu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 34 citations in OpenAlex.

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  5. Tumor-associated genetic amplifications impact extracellular vesicle miRNA cargo and their recruitment of nerves in head and neck cancer.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xiangbing WuSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 W. 15th Street, NB 500E, Indianapolis, IN, 46202, USA.
Chandler L WalkerSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 W. 15th Street, NB 500E, Indianapolis, IN, 46202, USA.
Qingbo LuSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 W. 15th Street, NB 500E, Indianapolis, IN, 46202, USA.
Wei WuSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 W. 15th Street, NB 500E, Indianapolis, IN, 46202, USA.
Daniel B EddelmanDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Jonathan M ParishDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Xiao-Ming XuSpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 W. 15th Street, NB 500E, Indianapolis, IN, 46202, USA. xu26@iupui.edu.
Neurological Surgery · USIndiana University – Purdue University Indianapolis · US

Funding

Reprogramming reactive glial cells into functional new neurons after SCIR01NS111776 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI WU, WEI, ZHANG, CHUN-LI · 2020 to 2024
$2.4M
Role of phospholipase A2 in spinal cord secondary injuryR01NS059622 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI XU, XIAO-MING · 2009 to 2013
$1.6M
Role of Acrolein in Spinal Cord InjuryR01NS073636 · NINDS · PURDUE UNIVERSITY · PI SHI, RIYI · 2012 to 2015
$1.4M
Constructing a growth-promoting pathway for functional regeneration after SCII01BX002356 · VA · RLR VA MEDICAL CENTER · PI BROWN, TODD J, JONES, KATHRYN JANE · 2015 to 2023
–
BLRD VA I01 BX002356Craig H. Neilsen Foundation 296749Indiana State Department of Health 13679NINDS NIH HHS NS059622NINDS NIH HHS NS073636NINDS NIH HHS R01 NS059622NINDS NIH HHS R01 NS073636NINDS NIH HHS R01 NS111776U.S. Department of Defense W81XWH-12-1-0562
6 · The paper itself

Abstract

Activation of RhoA/Rho kinase leads to growth cone collapse and neurite retraction. Although RhoA/Rho kinase inhibition has been shown to improve axon regeneration, remyelination and functional recovery, its role in neuronal cell death remains unclear. To determine whether RhoA/Rho kinase played a role in neuronal death after injury, we investigated the relationship between RhoA/Rho kinase and cytosolic phospholipase A

Indexed as

AnimalsCell DeathFemaleGroup IV Phospholipases A2MiceMice, Inbred C57BLNeuronsPregnancyRatsRats, Sprague-Dawleyrho-Associated KinasesGroup IV Phospholipases A2Pla2g4a protein, ratrho-Associated KinasesRock1 protein, mouseRock2 protein, mouseCell deathCytosolic phospholipase A2NeuroprotectionRhoARho kinaseSpinal cord injury

Identifiers

PMID27771900
PMCPMC9150929
OpenAlexW2535989135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.