ArticleClinical oral investigations2017
The mycobiome of root canal infections is correlated to the bacteriome.
Article in Clinical oral investigations, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Pooled it
- Modelling of the Systemic Inflammatory Host Response in Relation to the Microbiome of the Endodontic Infection.International endodontic journal · 2025Article
- Bacterial genera in the fluids from apical periodontitis-related radicular cysts: An observational study.International endodontic journal · 2025Observational
- A polymicrobial perspective into the ecological role of Enterococcus faecalis in dental root canal infections.NPJ biofilms and microbiomes · 2025Review
- Apical periodontitis microbiome association with salivary and serum inflammatory burden.International endodontic journal · 2025Article
- Article
- Occurrence rate and estimated economic burden of pulp and periapical disease treatment among Korean older adults: a national population-based retrospective study.Epidemiology and health · 2025Article
- Comparative in Vitro Study on the Antimicrobial Efficacy of Endodontic Sealers Against Common Oral Pathogens.Dentistry journal · 2024Article
- Intracanal microbiome profiles of two apical periodontitis cases in one patient: A comparison with saliva and plaque profiles.Clinical and experimental dental research · 2024Article
- Comparative analysis of hydrophobicity and dentin adhesion ability in Candida albicans strains.Journal of applied oral science : revista FOB · 2024Article
- Article
- Mycotoxins and Amyotrophic Lateral Sclerosis: Food Exposure, Nutritional Implications and Dietary Solutions.CNS & neurological disorders drug targets · 2024Review
- Correlating the succession of microbial communities from Nigerian soils to petroleum biodegradation.World journal of microbiology & biotechnology · 2023Article
- Recent progress in carbon dots for anti-pathogen applications in oral cavity.Frontiers in cellular and infection microbiology · 2023Review
- Antagonistic interaction between two key endodontic pathogensJournal of oral microbiology · 2023Article
- Economic analysis of the different endodontic instrumentation techniques used in the Unified Health System.BMC oral health · 2022Article
- Oil Absorbent Polypropylene Particles Stimulate Biodegradation of Crude Oil by Microbial Consortia.Frontiers in microbiology · 2022Article
- Correlating biodegradation kinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the dynamics of microbial communities originating from soil in Vietnam contaminated with herbicides and dioxins.Frontiers in microbiology · 2022Article
- Chitosan Enhances the Anti-Biofilm Activity of Biodentine against an Interkingdom Biofilm Model.Antibiotics (Basel, Switzerland) · 2021Article
- Effects of DNA preservation solution and DNA extraction methods on microbial community profiling of soil.Folia microbiologica · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesBacterial infection of the root canal system causes apical periodontitis. Less is known about the role of fungi in these infections. This study aimed to assess the fungal prevalence, abundance, and diversity of root canal infections, as well as the relation between fungi and bacteria present in different parts of the root canal. MATERIALS AND
methodsTwenty-six teeth with primary apical periodontitis were extracted, split in apical and coronal root segments, and cryo-pulverized. Bacteriome profiles of 23 teeth were analyzed based on the V3-V4 hypervariable region of the 16S ribosomal RNA gene. Mycobiome profiles of six teeth were analyzed based on the internal transcribed spacer (ITS) 1 or ITS2 region. Samples were sequenced on the Illumina MiSeq platform.
resultsA total of 338 bacterial operational taxonomic units (OTUs), 28 ITS1 OTUs, and 24 ITS2 OTUs were identified. Candida and Malassezia were the most frequently identified fungi. No differences could be found between the bacteriome and mycobiome profiles of the apical and coronal root segments. The bacteriome of fungi-positive root segments contained more Actinomyces, Bifidobacterium, four different Lactobacillus OTUs, Propionibacterium, and Streptococcus. A Spearman correlation matrix between bacteriomes and mycobiomes identified no correlations, but separate clusters could be observed.
conclusionsA considerable proportion of the root canal infections contain fungi, although fungal diversity is limited. However, when fungi are present, the composition of the bacteriome is clearly different. CLINICAL RELEVANCE: Interaction between bacteria and fungi in root canal infections may complicate the infection and require alternative treatment strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.