ReviewEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2017
Population attributable burden of Helicobacter pylori-related gastric cancer, coronary heart disease, and ischemic stroke in China.
Review in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 6 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Burden of gastric cancer attributable to Helicobacter pylori in 27 countries from seven geographic regions in 2022.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Pooled it
- An Updated Meta-Analysis of the Relationship BetweenFrontiers in cardiovascular medicine · 2022Pooled it
- Population Attributable Fraction of Helicobacter pylori Infection-Related Gastric Cancer in Korea: A Meta-Analysis.Cancer research and treatment · 2021Pooled it
- Antibiotics for secondary prevention of coronary heart disease.The Cochrane database of systematic reviews · 2021Pooled it
- Association of Helicobacter pylori with the Risk of Hepatic Encephalopathy.Digestive diseases and sciences · 2017Pooled it
- Association of Helicobacter pylori with Chronic Kidney Diseases: A Meta-Analysis.Digestive diseases and sciences · 2017Pooled it
- Prevalence, infection status and associated factors of H. Pylori among adult dyspeptic patients in Jalalabad, Afghanistan.BMC infectious diseases · 2026Article
- Methodological evaluation ofFrontiers in cellular and infection microbiology · 2026Article
- Trends and disparities in chronic ischemic heart disease mortality among adult cancer patients: a nationwide CDC WONDER analysis (1999-2020).Cardio-oncology (London, England) · 2025Article
- Trends in Stomach Cancer Burden in China: A Joinpoint and APC Analysis Based on GBD 2021.Journal of gastroenterology and hepatology · 2025Article
- Review
- Long-term trends and projections of stomach cancer burden in China: Insights from the GBD 2021 study.PloS one · 2025Article
- Article
- 2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part I.Acta Cardiologica Sinica · 2024Article
- Cardiovascular and Neurological Diseases and Association with Helicobacter Pylori Infection-An Overview.Diagnostics (Basel, Switzerland) · 2024Review
- Long-term Helicobacter pylori infection is associated with an increased risk of carotid plaque formation: a retrospective cohort study.Frontiers in cardiovascular medicine · 2024Article
- Chronic gastritis may predict risk of cerebral small vessel disease.BMC gastroenterology · 2023Article
- Helicobacter pylori Infection, Its Laboratory Diagnosis, and Antimicrobial Resistance: a Perspective of Clinical Relevance.Clinical microbiology reviews · 2022Review
- A nationwide cohort study suggests clarithromycin-based therapy for Helicobacter pylori eradication is safe in patients with stable coronary heart disease and subsequent peptic ulcer disease.BMC gastroenterology · 2022Article
- Epidemiology ofPeerJ · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori, a risk factor of cancer and chronic diseases, remains highly prevalent in China. This review aims to systematically evaluate the H. pylori-attributable burden for gastric cancer (GC), coronary heart disease (CHD), and ischemic stroke (IS) in the Chinese population. Helicobacter pylori prevalence was updated by pooling the results reported in studies across China. The population attributable fraction (PAF) was calculated based on the H. pylori prevalence 10 years ago and relative risks of specific disease by reviewing the prospective studies published from 2000 through 2015. In China, the nationwide average prevalence of H. pylori was estimated to be 42.06 % in the general population during 2009-2013. The fixed effects pooled relative risk (RR) of 1.89 [95 % confidence interval (CI): 1.57-2.26] was obtained for gastric cancer and H. pylori infection. Helicobacter pylori infection was responsible for around 37.38 % of noncardia GC, corresponding to about 105,536 cases in 2012. As for extra-gastric disorders, H. pylori infections had higher risk of CHD (RR = 1.55, 95 % CI: 1.37-1.76) and IS (RR = 1.54, 95 % CI: 1.42-1.66). About 23.15 % of CHD and 22.29 % of IS were attributable to H. pylori infection. The estimates of H. pylori-attributable burden reveal a great potential of reducing H. pylori-related chronic disease burden by H. pylori eradication. Large prospective studies are warranted to identify which H. pylori strains, which subtypes of the disease, and which subgroups of the population have the greatest risk of relevant diseases and the effect of H. pylori eradication on the prevention of H. pylori-related diseases.
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