ArticleActa neuropathologica2017
Reduced vascular amyloid burden at microhemorrhage sites in cerebral amyloid angiopathy.
Article in Acta neuropathologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Contrasting patterns of leptomeningeal and parenchymal gadolinium extravasation in cerebral amyloid angiopathy: An MRI-based evaluation.International journal of stroke : official journal of the International Stroke Society · 2026Article
- Arteriolar degeneration and stiffness in cerebral amyloid angiopathy are linked to Aβ deposition and lysyl oxidase.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Location and Timing of Recurrent, Nontraumatic Intracerebral Hemorrhage.JAMA neurology · 2025Article
- Sensitivity and Specificity of the Boston Criteria Version 2.0 for the Diagnosis of Cerebral Amyloid Angiopathy in a Community-Based Sample.Neurology · 2024Article
- Cerebral tau pathology in cerebral amyloid angiopathy.Brain communications · 2024Article
- Blood-brain barrier leakage and perivascular inflammation in cerebral amyloid angiopathy.Brain communications · 2022Article
- Vascular pathology and pathogenesis of cognitive impairment and dementia in older adults.Cerebral circulation - cognition and behavior · 2022Article
- Charcot-Bouchard aneurysms revisited: clinicopathologic correlations.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Age, sex, and cerebral microbleeds in EFAD Alzheimer disease mice.Neurobiology of aging · 2021Article
- Spectroscopic and deep learning-based approaches to identify and quantify cerebral microhemorrhages.Scientific reports · 2021Article
- Association of amyloid angiopathy with microbleeds in logopenic progressive aphasia: an imaging-pathology study.European journal of neurology · 2021Article
- Early MRI imaging and follow-up study in cerebral amyloid angiopathy.Open medicine (Warsaw, Poland) · 2021Article
- In vivo characterization of spontaneous microhemorrhage formation in mice with cerebral amyloid angiopathy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Disturbed balance in the expression of MMP9 and TIMP3 in cerebral amyloid angiopathy-related intracerebral haemorrhage.Acta neuropathologica communications · 2020Article
- Hereditary cerebral amyloid angiopathy, Piedmont-type mutation.Neurology. Genetics · 2020Article
- Different microvascular alterations underlie microbleeds and microinfarcts.Annals of neurology · 2019Article
- Article
- Advances in cerebral amyloid angiopathy imaging.Therapeutic advances in neurological disorders · 2019Review
- Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer's disease.Acta neuropathologica communications · 2018Article
- The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice.Journal of neurology, neurosurgery, and psychiatry · 2017Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Microhemorrhages are strongly associated with advanced cerebral amyloid angiopathy (CAA). Although it has been frequently proposed that the deposition of Aβ in the walls of cortical vessels directly causes microhemorrhages, this has not been studied in great detail, mainly because the ruptured vessels are often missed on routine histopathologic examination. Here, we examined histopathological data from studies targeting microhemorrhages with high-resolution ex vivo 7 T MRI in nine cases with moderate-to-severe CAA, and assessed the presence of Aβ in the walls of involved vessels. We also assessed the density of Aβ positive cortical vessels in areas surrounding microhemorrhages compared to control areas. In seven out of 19 microhemorrhages, the presumed involved vessel could be identified on the histopathological section. Only one of these vessels was positive for Aβ at the site of rupture. Moreover, the density of Aβ positive cortical vessels was lower (1.0 per mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.