ArticleJournal of molecular biology2017
ClusPro-DC: Dimer Classification by the Cluspro Server for Protein-Protein Docking.
Article in Journal of molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Towards precision epitopes based vaccine againstBiochemistry and biophysics reports · 2025Article
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- Rapid and accurate prediction of protein homo-oligomer symmetry using Seq2Symm.Nature communications · 2025Article
- Structural categorization and identification of electrostatic interactions in two proposed human serum albumin dimerization patterns and dipyridamole interaction.Turkish journal of chemistry · 2025Article
- Domain architecture of theHeliyon · 2024Article
- Structural modeling and characterization of the Mycobacterium tuberculosis MmpL3 C-terminal domain.FEBS letters · 2024Article
- CHIP drives proteasomal degradation of NUR77 to alleviate oxidative stress and intrinsic apoptosis in cisplatin-induced nephropathy.Communications biology · 2024Article
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- Comparative analysis, diversification, and functional validation of plant nucleotide-binding site domain genes.Scientific reports · 2024Article
- Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis.Nature communications · 2024Article
- Rapid and accurate prediction of protein homo-oligomer symmetry with Seq2Symm.Research square · 2024Article
- The protein common assembly database (ProtCAD)-a comprehensive structural resource of protein complexes.Nucleic acids research · 2023Article
- PDB-wide identification of physiological hetero-oligomeric assemblies based on conserved quaternary structure geometry.Structure (London, England : 1993) · 2021Article
- Modeling and Structure Determination of Homo-Oligomeric Proteins: An Overview of Challenges and Current Approaches.International journal of molecular sciences · 2021Review
- Article
- Challenges in protein docking.Current opinion in structural biology · 2020Review
- ClusPro in rounds 38 to 45 of CAPRI: Toward combining template-based methods with free docking.Proteins · 2020Article
- Exploration of surface glycoprotein to design multi-epitope vaccine for the prevention of Covid-19.Informatics in medicine unlocked · 2020Article
- Template-based modeling by ClusPro in CASP13 and the potential for using co-evolutionary information in docking.Proteins · 2019Article
- Principles and characteristics of biological assemblies in experimentally determined protein structures.Current opinion in structural biology · 2019Review
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Authors and funding
6 authors.
Funding
Abstract
ClusPro-DC (https://cluspro.bu.edu/) implements a straightforward approach to the discrimination between crystallographic and biological dimers by docking the two subunits to exhaustively sample the interaction energy landscape. If a substantial number of low energy docked poses cluster in a narrow vicinity of the native structure of the dimer, then one can assume that there is a well-defined free energy well around the native state, which makes the interaction stable. In contrast, if the interaction sites in the docked poses do not form a large enough cluster around the native structure, then it is unlikely that the subunits form a stable biological dimer. The number of near-native structures is used to estimate the probability of a dimer being biological. Currently, the server examines only the stability of a given interface rather than generating all putative quaternary structures as accomplished by PISA or EPPIC, but it complements the information provided by these methods.
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