Evidence map›Paper›PMID 27771430›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2017

Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy.

Timothy M Brenza, Shivani Ghaisas, Julia E Vela Ramirez, Dilshan Harischandra, Vellareddy Anantharam, Balaraman Kalyanaraman, Anumantha G Kanthasamy, Balaji Narasimhan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 98 citations in OpenAlex.

  1. Review
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  4. Targeting respiratory virus-induced reactive oxygen species in airways diseases.European respiratory review : an official journal of the European Respiratory Society · 2025
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  13. Mitochondrial-targeting MnRegenerative biomaterials · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Timothy M BrenzaDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA.
Shivani GhaisasDepartment of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Julia E Vela RamirezDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA.
Dilshan HarischandraDepartment of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Vellareddy AnantharamDepartment of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Balaraman KalyanaramanDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.
Anumantha G KanthasamyDepartment of Biomedical Sciences, Iowa State University, Ames, IA, USA. Electronic address: akanthas@iastate.edu.
Balaji NarasimhanDepartment of Chemical and Biological Engineering, Iowa State University, Ames, IA, USA. Electronic address: nbalaji@iastate.edu.
Iowa State University · USMedical College of Wisconsin · US

Funding

MMT, DOPAMINERGIC DEGENERATION, AND AGINGR01ES010586 · NIEHS · IOWA STATE UNIVERSITY · PI KANTHASAMY, ANUMANTHA GOUNDER · 2000 to 2015
$4.6M
Oxidative Stress Induced Compensatory Protective Mechanisms in PDR01NS074443 · NINDS · IOWA STATE UNIVERSITY · PI KANTHASAMY, ANUMANTHA GOUNDER · 2011 to 2015
$1.6M
NIEHS NIH HHS R01 ES010586NINDS NIH HHS R01 NS074443
6 · The paper itself

Abstract

A progressive loss of neuronal structure and function is a signature of many neurodegenerative conditions including chronic traumatic encephalopathy, Parkinson's, Huntington's and Alzheimer's diseases. Mitochondrial dysfunction and oxidative and nitrative stress have been implicated as key pathological mechanisms underlying the neurodegenerative processes. However, current therapeutic approaches targeting oxidative damage are ineffective in preventing the progression of neurodegeneration. Mitochondria-targeted antioxidants were recently shown to alleviate oxidative damage. In this work, we investigated the delivery of biodegradable polyanhydride nanoparticles containing the mitochondria-targeted antioxidant apocynin to neuronal cells and the ability of the nano-formulation to protect cells against oxidative stress. The nano-formulated mitochondria-targeted apocynin provided excellent protection against oxidative stress-induced mitochondrial dysfunction and neuronal damage in a dopaminergic neuronal cell line, mouse primary cortical neurons, and a human mesencephalic cell line. Collectively, our results demonstrate that nano-formulated mitochondria-targeted apocynin may offer improved efficacy of mitochondria-targeted antioxidants to treat neurodegenerative disease.

Indexed as

AcetophenonesAnimalsAntioxidantsCell LineCells, CulturedDrug CarriersDrug Delivery SystemsHumansMiceMitochondriaNanoparticlesNeuronsNeuroprotectionOxidative StressPolyanhydridesAcetophenonesacetovanilloneAntioxidantsDrug CarriersPolyanhydridesMito-apocyninNeurodegenerationOxidative stressPolyanhydride nanoparticles

Identifiers

PMID27771430
PMCPMC5392427
OpenAlexW2536564962

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.