ReviewThe ocular surface2017
In Vivo Confocal Microscopy of Corneal Nerves in Health and Disease.
Review in The ocular surface, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04439552 (Neuroplasticity of Pain Pathways and Corneal Afferent Regeneration Following Corneal Crosslinking), which is not on this map. Cited by 186 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuroplasticity of Pain Pathways and Corneal Afferent Regeneration Following Corneal Crosslinking (CXL) in Keratoconus
Who cites it
186 citing papers in PubMed, 3 syntheses or guidelines pooled it, 350 citations in OpenAlex.
- Identification of presumed corneal neuromas and microneuromas using laser-scanning in vivo confocal microscopy: a systematic review.The British journal of ophthalmology · 2022Pooled it
- CornealFrontiers in medicine · 2022Pooled it
- Pooled it
- Impact of corneal parameters, refractive error and age on density and morphology of the subbasal nerve plexus fibers in healthy adults.Scientific reports · 2021Trial
- Topical citicoline and vitamin B12 versus placebo in the treatment of diabetes-related corneal nerve damage: a randomized double-blind controlled trial.BMC ophthalmology · 2020Trial
- Corneal nerve regeneration: treatments and monitoring approaches.Annals of medicine · 2026Review
- Panoramic Two-Photon Imaging and Quantitative Analysis of the Corneal Sub-Basal Nerve Plexus.Ophthalmology science · 2026Article
- The miR-183/96/182 Cluster Regulates Trigeminal Ganglion Sensory Neurons' Response toPathogens (Basel, Switzerland) · 2026Article
- The combined use of in vivo confocal microscopy and optical coherence tomography in monitoring corneal infections.Eye (London, England) · 2026Article
- Chronic Ocular Surface Pain: A Missing Member of the Chronic Overlapping Pain Conditions?Drugs · 2026Review
- Preclinical Safety and Feasibility Study of Line-Field Confocal Optical Coherence Tomography for Ophthalmology Applications.Translational vision science & technology · 2026Article
- Corneal Innervation Research at a Crossroads: A Tool-Driven Roadmap for the Future.Investigative ophthalmology & visual science · 2026Review
- Automated dual-camera DMD system for stereo optical sectioning imaging.Biomedical optics express · 2026Article
- Information Entropy-Based Framework for Quantifying Curve Tortuosity in Meibomian Glands Uneven Atrophy.Translational vision science & technology · 2026Article
- Large-area 3D reconstruction of corneal tissues from oscillating focus confocal microscopy.Scientific reports · 2026Article
- The miR-183/96/182 Cluster Regulates Trigeminal Ganglion Sensory Neurons' Response tobioRxiv : the preprint server for biology · 2026Article
- Review
- The Role of Innervation in Ocular Surface Homeostasis, Tissue Remodeling Following Nerve Injury, and the Therapeutic Potential of Hemocomponents in Neuronal and Cicatricial Pathologies.Journal of clinical medicine · 2026Review
- Clusterin reverses epitheliopathy, reduces inflammation, and restores goblet cells and corneal nerves in a mouse model of autoimmune dry eye.Scientific reports · 2026Article
- Emerging Technologies in Corneal Nerve Evaluation for Dry Eye and Ocular Surface Disease: A Review.Journal of clinical medicine · 2026Review
126 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
In vivo confocal microscopy (IVCM) is becoming an indispensable tool for studying corneal physiology and disease. Enabling the dissection of corneal architecture at a cellular level, this technique offers fast and noninvasive in vivo imaging of the cornea with images comparable to those of ex vivo histochemical techniques. Corneal nerves bear substantial relevance to clinicians and scientists alike, given their pivotal roles in regulation of corneal sensation, maintenance of epithelial integrity, as well as proliferation and promotion of wound healing. Thus, IVCM offers a unique method to study corneal nerve alterations in a myriad of conditions, such as ocular and systemic diseases and following corneal surgery, without altering the tissue microenvironment. Of particular interest has been the correlation of corneal subbasal nerves to their function, which has been studied in normal eyes, contact lens wearers, and patients with keratoconus, infectious keratitis, corneal dystrophies, and neurotrophic keratopathy. Longitudinal studies have applied IVCM to investigate the effects of corneal surgery on nerves, demonstrating their regenerative capacity. IVCM is increasingly important in the diagnosis and management of systemic conditions such as peripheral diabetic neuropathy and, more recently, in ocular diseases. In this review, we outline the principles and applications of IVCM in the study of corneal nerves in various ocular and systemic diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.