Evidence map›Paper›PMID 27771280›Full record

ArticleUrologic oncology2017

Longer average blood storage duration is associated with increased risk of infection and overall morbidity following radical cystectomy.

Meera R Chappidi, Heather J Chalfin, Daniel J Johnson, Max Kates, Nikolai A Sopko, Michael H Johnson, Jen-Jane Liu, Steven M Frank, Trinity J Bivalacqua

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In one paragraph

Article in Urologic oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meera R ChappidiThe James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: mchappi1@jhmi.edu.
Heather J ChalfinThe James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD.
Daniel J JohnsonDepartment of Anesthesiology/Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.
Max KatesThe James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD.
Nikolai A SopkoThe James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD.
Michael H JohnsonThe James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD.
Jen-Jane LiuDepartment of Urology, Oregon Health & Science University, Portland, OR.
Steven M FrankDepartment of Anesthesiology/Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.
Trinity J BivalacquaThe James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD.

Funding

Institute for Clinical and Translational ResearchTL1TR001078 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$1.9M
Molecular Analysis and Precision Medicine in Renal Cell CarcinomaK01ES026838 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI JOHNSON, MICHAEL HIROSHI · 2015 to 2019
$821k
NCATS NIH HHS TL1 TR001078NIEHS NIH HHS K01 ES026838
6 · The paper itself

Abstract

backgroundPatients with bladder cancer undergoing radical cystectomy (RC) experience high rates of perioperative blood transfusions (PBTs) and morbidity. The aim of this study was to evaluate the effect of blood storage duration on the risk of adverse perioperative outcomes in this high-risk patient population. MATERIALS AND

methodsIn a retrospective review of RC patients from 2010 to 2014 who received PBTs, the average storage duration for all units transfused was used to classify patients as receiving older blood using 3 different definitions (≥21 days,≥28 days, and≥35 days). Multivariable Poisson regression models were used to determine the adjusted relative risk of perioperative infections and overall morbidity in those given older blood compared to fresher blood.

resultsOf the 451 patients undergoing RC, 205 (45%) received nonirradiated PBTs. In multivariable modeling, increasing average blood storage duration, as a continuous variable, was associated with an increased risk of infections (risk ratio [RR] = 1.08 per day, 95% CI: 1.01-1.17) and overall morbidity (RR = 1.08 per day, 95% CI: 1.01-1.15). Furthermore, ≥28-day blood storage (vs.<28) was associated with increased infections (RR = 2.69, 95% CI: 1.18-6.14) and morbidity (RR = 2.54, 95% CI: 1.31-4.95), and ≥35-day blood storage (vs.<35) was also associated with increased infections (RR = 2.83, 95% CI: 1.42-5.66) and morbidity (RR = 3.35, 95% CI: 1.95-5.77).

conclusionsAlthough blood is stored up to 42 days, storage≥28 days may expose RC patients to increased perioperative infections and overall morbidity compared with storage<28 days. Prospective cohort studies are warranted in cystectomy and other high-risk surgical oncology patients to better determine the effect of blood storage duration.

Indexed as

AgedBlood PreservationBlood TransfusionComorbidityCystectomyFemaleHumansInfectionsMaleMiddle AgedOutcome Assessment, Health CareRetrospective StudiesRisk FactorsTime FactorsUrinary Bladder NeoplasmsBladder cancerBlood transfusionCystectomyInfectionPostoperative complications

Identifiers

PMID27771280
PMCPMC5222715

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.