Evidence map›Paper›PMID 27771165›Full record

ArticleGynecologic oncology2016

Endoplasmic reticulum stress in complex atypical hyperplasia as a possible predictor of occult carcinoma and progestin response.

Katherine E Tierney, Lingyun Ji, Shannon S Dralla, Eunjeong Yoo, Annie Yessaian, Huyen Q Pham, Lynda Roman, Richard Sposto, Paulette Mhawech-Fauceglia, Yvonne G Lin

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PubMed Full text at PMC Publisher
In one paragraph

Article in Gynecologic oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Improving response to progestin treatment of low-grade endometrial cancer.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2020
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Katherine E TierneyDivision of Gynecologic Oncology, Department of Obstetrics/Gynecology, University of Southern California, Los Angeles, CA, United States.
Lingyun JiBiostatistics Shared Resource, USC Norris Comprehensive Cancer Center, and Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Shannon S DrallaDivision of Gynecologic Oncology, Department of Obstetrics/Gynecology, University of Southern California, Los Angeles, CA, United States.
Eunjeong YooWomen's Cancer Program, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United States.
Annie YessaianDivision of Gynecologic Oncology, Department of Obstetrics/Gynecology, University of Southern California, Los Angeles, CA, United States.
Huyen Q PhamDivision of Gynecologic Oncology, Department of Obstetrics/Gynecology, University of Southern California, Los Angeles, CA, United States.
Lynda RomanDivision of Gynecologic Oncology, Department of Obstetrics/Gynecology, University of Southern California, Los Angeles, CA, United States.
Richard SpostoBiostatistics Shared Resource, USC Norris Comprehensive Cancer Center, and Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Paulette Mhawech-FaucegliaDepartment of Pathology and Gynecologic Oncology, University of Southern California, Los Angeles, CA, United States. Electronic address: pfauceglia@hotmail.com.
Yvonne G LinDivision of Gynecologic Oncology, Department of Obstetrics/Gynecology, University of Southern California, Los Angeles, CA, United States; Women's Cancer Program, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United States.
University of Southern California · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
NCI NIH HHS P30 CA014089
6 · The paper itself

Abstract

Glucose-regulated protein (GRP)-78, the key regulator of endoplasmic reticulum (ER) stress, is associated with endometrial cancer (EC) development and progression. However, its role in the continuum from complex atypical hyperplasia (CAH) to EC is unknown and the focus of this study.

methods252 formalin-fixed, paraffin-embedded endometrial biopsies from patients with CAH diagnosed between 2003 and 2011 were evaluated for GRP78 expression by immunohistochemistry. Expression was also evaluated in subsequent biopsies from those patients treated with progestins. Differences in GRP78 expression were assessed using standard statistical methods.

resultsGRP78 expression was undetectable in 45(18%) patients with CAH, while 120(48%) CAH cases showed moderate/strong expression. Among women who ultimately underwent hysterectomy for CAH (n=134), 54(40%) had occult EC while 57(43%) had persistent CAH. Those with occult EC upon hysterectomy had significantly stronger GRP78 expression than those who did not have occult EC (p=0.007). Greater GRP78 expression within CAH remained independently associated with the presence of an occult EC (p=0.017). Thirty-four of 54 (63%) patients with occult EC had moderate/strong GRP78 expression compared to 36 of 80 (45%) patients with persistent CAH, benign or non-atypical hyperplastic endometrium. In those treated with progestins, samples with persistent CAH and EC were more likely to have high levels of GRP78 expression in the initial biopsies than those who responded (p=0.014).

conclusionsIncreased GRP78 expression in untreated CAH correlates with the presence of an occult EC. In addition, CAH specimens with greater GRP78 expression may identify patients who are less likely to respond to progestin therapy.

Indexed as

Endoplasmic Reticulum StressAdolescentAdultAgedCarcinoma, EndometrioidEndometrial HyperplasiaEndometrial NeoplasmsEndoplasmic Reticulum Chaperone BiPFemaleHeat-Shock ProteinsHumansHysterectomyImmunohistochemistryMiddle AgedProgestinsTreatment OutcomeEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHSPA5 protein, humanProgestinsEndometrial hyperplasiaGRP78ImmunohistochemistryOccult endometrioid adenocarcinomaResponse to therapy

Identifiers

PMID27771165
PMCPMC7474546
OpenAlexW2535782974

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.