ArticleOphthalmology2016
Heritability of Choroidal Thickness in the Amish.
Article in Ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Unraveling the Heritability of Ocular Rigidity and Myopia-Related Traits: A Siblings-Based Study.Investigative ophthalmology & visual science · 2026Article
- Quantitative Choroidal Analysis of Molecularly Characterized Retinitis Pigmentosa.Investigative ophthalmology & visual science · 2025Article
- Genetic influence on choroidal vascularity index.PloS one · 2025Article
- Article
- Genetic Variability of Complement Factor H Has Ethnicity-Specific Associations With Choroidal Thickness.Investigative ophthalmology & visual science · 2023Article
- Choroidal Thickness in Early Postnatal Guinea Pigs Predicts Subsequent Naturally Occurring and Form-Deprivation Myopia.Investigative ophthalmology & visual science · 2022Article
- Consequences of a Rare Complement Factor H Variant for Age-Related Macular Degeneration in the Amish.Investigative ophthalmology & visual science · 2022Article
- The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish.HGG advances · 2022Article
- Genomewide Association Study of Retinal Traits in the Amish Reveals Loci Influencing Drusen Development and Link to Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2022Article
- The GGLEAM Study: Understanding Glaucoma in the Ohio Amish.International journal of environmental research and public health · 2021Article
- Quantitative Assessment of Asymmetric Choroidal Outflow in Pachychoroid Eyes on Ultra-Widefield Indocyanine Green Angiography.Investigative ophthalmology & visual science · 2020Article
- Heritability of Inner Retinal Layer and Outer Retinal Layer Thickness: The Healthy Twin Study.Scientific reports · 2020Article
- Rare variants and loci for age-related macular degeneration in the Ohio and Indiana Amish.Human genetics · 2019Article
- AMISH EYE STUDY: Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration.Retina (Philadelphia, Pa.) · 2019Article
- Pachychoroid disease.Eye (London, England) · 2019Review
- CONCURRENT IDIOPATHIC MACULAR TELANGIECTASIA TYPE 2 AND CENTRAL SEROUS CHORIORETINOPATHY.Retina (Philadelphia, Pa.) · 2018Observational
- Co occurrance of Macular Telangiectasia type 2 with hemorrhagic polypoidal choroidal vasculopathy and response to anti-vascular endothelial growth factor.Oman journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
Abstract
purposeTo evaluate the heritability of choroidal thickness and its relationship to age-related macular degeneration (AMD).
designCohort study.
participantsSix hundred eighty-nine individuals from Amish families with early or intermediate AMD.
methodsOcular coherence tomography was used to quantify choroidal thickness, and fundus photography was used to classify eyes into categories using a modified Clinical Age-Related Maculopathy Staging (CARMS) system. Repeatability and heritability of choroidal thickness and its phenotypic and genetic correlations with the AMD phenotype (CARMS category) were estimated using a generalized linear mixed model (GLMM) approach that accounted for relatedness, repeated measures (left and right eyes), and the effects of age, gender, and refraction.
main outcome measuresHeritability of choroidal thickness and its phenotypic and genetic correlation with the AMD phenotype (CARMS category).
resultsPhenotypic correlation between choroidal thickness and CARMS category was moderate (Spearman's rank correlation, r
conclusionsWe quantify the heritability of choroidal thickness for the first time, highlighting a heritable, quantitative trait that is measurable in all individuals regardless of AMD affection status, and moderately phenotypically correlated with AMD severity. Choroidal thickness therefore may capture variation not captured by the CARMS system. However, because the genetic correlation between choroidal thickness and AMD severity was not significant in our data set, genes associated with the 2 traits may not overlap substantially. Future studies should therefore test for genetic variation associated with choroidal thickness to determine the overlap in genetic basis with AMD.
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Registered trials
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