Evidence map›Paper›PMID 27770831›Full record

ArticleArthritis research & therapy2016

Association of anti-peptidyl arginine deiminase antibodies with radiographic severity of rheumatoid arthritis in African Americans.

Iris Navarro-Millán, Erika Darrah, Andrew O Westfall, Ted R Mikuls, Richard J Reynolds, Maria I Danila, Jeffrey R Curtis, CLEAR Investigators, Antony Rosen, S Louis Bridges

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  16. Systemic levels of anti-PAD4 autoantibodies correlate with airway obstruction in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2019
    Article
  17. Article
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  20. Rheumatoid arthritis and citrullination.Current opinion in rheumatology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Iris Navarro-MillánUniversity of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower 850, Birmingham, AL, 35294-3408, USA. inavarro@uabmc.edu.ORCID 0000-0001-6963-427X
Erika DarrahDivision of Rheumatology, The Johns Hopkins University, Baltimore, MD, USA.
Andrew O WestfallUniversity of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower 850, Birmingham, AL, 35294-3408, USA.
Ted R MikulsVA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, USA.
Richard J ReynoldsUniversity of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower 850, Birmingham, AL, 35294-3408, USA.
Maria I DanilaUniversity of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower 850, Birmingham, AL, 35294-3408, USA.
Jeffrey R CurtisUniversity of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower 850, Birmingham, AL, 35294-3408, USA.
CLEAR Investigators
Antony RosenDivision of Rheumatology, The Johns Hopkins University, Baltimore, MD, USA.
S Louis BridgesUniversity of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower 850, Birmingham, AL, 35294-3408, USA.
University of Alabama at Birmingham · USJohns Hopkins University · US

Funding

Phenotype-Specific Immune Responses in the Systemic VasculitidesP30AR053503 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI BINGHAM, CLIFTON O · 2006 to 2015
$6.4M
Dissection of the ACPA response in African-Americans with Rheumatoid ArthritisR01AR062376 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRIDGES, S LOUIS · 2011 to 2014
$1.7M
Genetic Architecture of Rheumatoid Arthritis in African-AmericansK23AR062100 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DANILA, MARIA IOANA · 2012 to 2016
$674k
Discovering Novel Genetic and Environmental Risk Factors for RA in African AmericK01AR060848 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI REYNOLDS, RICHARD JAMES · 2011 to 2015
$641k
NIAMS NIH HHS K01 AR060848NIAMS NIH HHS K23 AR062100NIAMS NIH HHS P30 AR053503NIAMS NIH HHS R01 AR062376
6 · The paper itself

Abstract

backgroundEvidence suggests that the presence of peptidyl arginine deiminase type 4 (PAD4) antibodies is associated with radiographic-severity rheumatoid arthritis (RA) among Caucasian patients. The presence of anti-PAD4 antibodies that were cross-reactivity against PAD3 was associated with more aggressive erosive disease (compared with the presence of anti-PAD4 antibodies without anti-PAD3 crossreactivity) in Caucasian RA patients. The objectives of this study were to determine the prevalence of serum anti-PAD4 and anti-PAD4/PAD3 cross-reactive autoantibodies in African Americans with RA and whether these antibodies associate with radiographic severity and radiographic progression.

methodsSerum anti-PAD4 and anti-PAD4/PAD3 antibodies were measured by immunoprecipitation, and the temporal trends in titers were analyzed. We compared total radiographic scores among anti-PAD4-positive, anti-PAD4/PAD3-positive, and anti-PAD4-negative patients and used a zero-inflated negative binomial model to determine associations between radiographic severity and antibody status. Logistic regression was used to analyze radiographic progression.

resultsOf 192 African-American patients with RA, 73 % were anti-citrullinated peptide/protein antibody (ACPA)-positive, 46 out of 192 (24 %) of whom had serum anti-PAD4 antibodies. Median (interquartile range) total Sharp van der Heijde radiographic scores were 2 (1-97.5) in ACPA-positive patients and 0 (0-3) in ACPA-negative patients (P < 0.001). Of the 46 anti-PAD4-positive patients, 20 had anti-PAD4 antibodies that cross-reacted with PAD3. In patients with early RA, anti-PAD4 and anti-PAD4/PAD3 antibody titers increased over time (P = 0.006, P = 0.001, respectively). Median (interquartile range) total radiographic scores were higher for anti-PAD4-positive than for anti-PAD4-negative patients (3 (1-115) versus 2 (0-11), respectively; P = 0.005). Median (interquartile range) total radiographic score for anti-PAD4/PAD3-positive patients was 76 (3-117) (P < 0.001) versus anti-PAD4-negative patients. Only anti-PAD4/PAD3 antibodies associated with radiographic severity (incidence rate ratio = 2.81; 95 % confidence interval 1.23, 6.43).

conclusionThis analysis suggests that autoantibodies against PAD4 and PAD3 proteins may serve as biomarkers for identifying African-American patients with RA and higher radiographic severity.

Indexed as

AdultAgedArthritis, RheumatoidAutoantibodiesAutoantigensBiomarkersBlack or African AmericanCohort StudiesCross ReactionsDisease ProgressionFemaleHumansHydrolasesImmunoprecipitationLongitudinal StudiesMaleAutoantibodiesAutoantigensBiomarkersHydrolasesPADI4 protein, humanProtein-Arginine DeiminasesProtein-Arginine Deiminase Type 4African AmericanAnti-PAD4Radiographic severityRheumatoid arthritis

Identifiers

PMID27770831
PMCPMC5075170
OpenAlexW2532688966

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.