Evidence map›Paper›PMID 27770823›Full record

ArticleArthritis research & therapy2016

Body mass index and extent of MRI-detected inflammation: opposite effects in rheumatoid arthritis versus other arthritides and asymptomatic persons.

Lukas Mangnus, Wouter P Nieuwenhuis, Hanna W van Steenbergen, Tom W J Huizinga, Monique Reijnierse, Annette H M van der Helm-van Mil

Open access · goldAbstract read
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In one paragraph

Article in Arthritis research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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  5. [Correlation analysis between body mass index and clinical characteristics of rheumatoid arthritis].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lukas MangnusDepartment of Rheumatology, Leiden University Medical Center, P.O. Box 9600, Leiden, 2300 RC, The Netherlands. l.mangnus@lumc.nl.ORCID 0000-0001-6978-0680
Wouter P NieuwenhuisDepartment of Rheumatology, Leiden University Medical Center, P.O. Box 9600, Leiden, 2300 RC, The Netherlands.
Hanna W van SteenbergenDepartment of Rheumatology, Leiden University Medical Center, P.O. Box 9600, Leiden, 2300 RC, The Netherlands.
Tom W J HuizingaDepartment of Rheumatology, Leiden University Medical Center, P.O. Box 9600, Leiden, 2300 RC, The Netherlands.
Monique ReijnierseDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Annette H M van der Helm-van MilDepartment of Rheumatology, Leiden University Medical Center, P.O. Box 9600, Leiden, 2300 RC, The Netherlands.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the population a high body mass index (BMI) has been associated with slightly increased inflammatory markers. Within rheumatoid arthritis (RA), however, a high BMI has been associated with less radiographic progression; this phenomenon is unexplained. We hypothesized that the phenomenon is caused by an inverse relationship between BMI and inflammation in hand and foot joints with RA. To explore this hypothesis, local inflammation was measured using magnetic resonance imaging (MRI) in early arthritis patients presenting with RA or other arthritides and in asymptomatic volunteers.

methodsA total of 195 RA patients, 159 patients with other inflammatory arthritides included in the Leiden Early Arthritis Clinic, and 193 asymptomatic volunteers underwent a unilateral contrast-enhanced 1.5 T MRI scan of metacarpophalangeal, wrist, and metatarsophalangeal joints. Each MRI scan was scored by two readers on synovitis, bone marrow edema (BME), and tenosynovitis; the sum yielded the total MRI inflammation score. Linear regression on log-transformed MRI data was used.

resultsA higher BMI was associated with higher MRI inflammation scores in arthritides other than RA (β = 1.082, p < 0.001) and in asymptomatic volunteers (β = 1.029, p = 0.040), whereas it was associated with lower MRI inflammation scores in RA (β = 0.97, p = 0.005). Evaluating the different types of inflammation, a higher BMI was associated with higher synovitis, BME, and tenosynovitis scores in arthritides other than RA (respectively β = 1.084, p < 0.001, β = 1.021, p = 0.24, and β = 1.054, p = 0.003), but with lower synovitis and BME scores in RA (respectively β = 0.98, p = 0.047 and β = 0.95, p = 0.002).

conclusionsIncreased BMI is correlated with less severe MRI-detected synovitis and BME in RA. This might explain the paradox in RA where obesity correlates with less severe radiographic progression.

Indexed as

AgedArthritisArthritis, RheumatoidBody Mass IndexBone MarrowCross-Sectional StudiesEdemaFemaleHumansImage Interpretation, Computer-AssistedInflammationMagnetic Resonance ImagingMaleMetacarpophalangeal JointMetatarsophalangeal JointMiddle AgedAsymptomatic volunteersBody mass indexInflammationMagnetic resonance imagingRheumatoid arthritis

Identifiers

PMID27770823
PMCPMC5075146
OpenAlexW2538452555

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.