Evidence map›Paper›PMID 27770815›Full record

ArticleJournal of translational medicine2016

Human endometrial regenerative cells alleviate carbon tetrachloride-induced acute liver injury in mice.

Shanzheng Lu, Ganggang Shi, Xiaoxi Xu, Grace Wang, Xu Lan, Peng Sun, Xiang Li, Baoren Zhang, Xiangying Gu, Thomas E Ichim and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Animal models accurately representing acute liver failure (Review).International journal of molecular medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Shanzheng LuDepartment of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
Ganggang ShiDepartment of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
Xiaoxi XuDepartment of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
Grace WangFaculty of Medicine, University of Toronto, Toronto, ON, Canada.
Xu LanDepartment of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
Peng SunDepartment of General Surgery, Affiliated Hospital of Weifang Medical University, Shandong, China.
Xiang LiDepartment of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
Baoren ZhangDepartment of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
Xiangying GuDepartment of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China.
Thomas E IchimImmune Advisors LLC, San Diego, CA, 92121, USA.
Hao WangDepartment of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China. hwangca272@hotmail.com.
Tianjin Medical University · CNTianjin Medical University General Hospital · CNHealthcentric Advisors · USUniversity of Toronto · CAWeifang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe endometrial regenerative cell (ERC) is a novel type of adult mesenchymal stem cell isolated from menstrual blood. Previous studies demonstrated that ERCs possess unique immunoregulatory properties in vitro and in vivo, as well as the ability to differentiate into functional hepatocyte-like cells. For these reasons, the present study was undertaken to explore the effects of ERCs on carbon tetrachloride (CCl

methodsAn ALI model in C57BL/6 mice was induced by administration of intraperitoneal injection of CCl

resultsERC treatment effectively decreased the CCl

conclusionsHuman ERCs protect the liver from acute injury in mice through hepatocyte proliferation promotion, as well as through anti-inflammatory and immunoregulatory effects.

Indexed as

AdultAnimalsAntigens, CDCarbon TetrachlorideCell ProliferationCytokinesEndometriumFemaleHepatocytesHistocompatibility Antigens Class IIHumansLiverLiver Function TestsMaleMice, Inbred C57BLNeutrophil InfiltrationAntigens, CDCarbon TetrachlorideCytokinesHistocompatibility Antigens Class IIOrganic ChemicalsPKH 26Acute liver injuryAnti-inflammatoryEndometrial regenerative cellsImmunoregulation

Identifiers

PMID27770815
PMCPMC5075169
OpenAlexW2538977980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.