ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2017
Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans.
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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 5 of them syntheses that pooled it.
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61citing papers in PubMed, 5 pooled it
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Who cites it
61 citing papers in PubMed, 5 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Assessing the lack of diversity in genetics research across neurodegenerative diseases: A systematic review of the GWAS Catalog and literature.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- African ancestry GWAS of dementia in a large military cohort identifies significant risk loci.Molecular psychiatry · 2023Pooled it
- Genetic Variability in Molecular Pathways Implicated in Alzheimer's Disease: A Comprehensive Review.Frontiers in aging neuroscience · 2021Pooled it
- Interpretation of risk loci from genome-wide association studies of Alzheimer's disease.The Lancet. Neurology · 2020Pooled it
- A randomized controlled trial to test the efficacy of a diabetes behavioral intervention to prevent memory decline in older blacks/African Americans with diabetes and mild cognitive impairment.Contemporary clinical trials · 2022Trial
- Race modifies the relationship between cognition and Alzheimer's disease cerebrospinal fluid biomarkers.Alzheimer's research & therapy · 2017Trial
- Cross-tissue graph attention networks for semi-supervised gene expression prediction.Briefings in bioinformatics · 2026Article
- Comprehensive adjudication identifies 111 high-confidence loci for Alzheimer's disease and related dementias.medRxiv : the preprint server for health sciences · 2026Article
- Artificial intelligence-driven multi-omics approaches in Alzheimer's disease: Progress, challenges, and future directions.Acta pharmaceutica Sinica. B · 2025Review
- Developing non-invasive molecular markers for early risk assessment of Alzheimer's disease.Biomarkers in neuropsychiatry · 2025Article
- Navigating the blurred boundary: Neuropathologic changes versus clinical symptoms in Alzheimer's disease, and its consequences for research in genetics.Journal of Alzheimer's disease : JAD · 2025Review
- Gaining insights into Alzheimer's disease by predicting chromatin spatial organization.Bioinformatics advances · 2025Article
- GRB14: A prognostic biomarker driving tumor progression in gastric cancer through the PI3K/AKT signaling pathway by interacting with COBLL1.Open life sciences · 2025Article
- Partial FAM19A5 deficiency in mice leads to disrupted spine maturation, hyperactivity, and an altered fear response.PloS one · 2025Article
- Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens.Human genomics · 2024Review
- Social determinants of health but not global genetic ancestry predict dementia prevalence in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- A comparative study of structural variant calling in WGS from Alzheimer's disease families.Life science alliance · 2024Article
- Assessing the lack of diversity in genetics research across neurodegenerative diseases: a systematic review of the GWAS Catalog and literature.medRxiv : the preprint server for health sciences · 2024Article
- The ROSMAP project: aging and neurodegenerative diseases through omic sciences.Frontiers in neuroinformatics · 2024Review
1 more citing papers are in PubMed but not listed here.
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Authors and funding
30 authors at 17 institutions in 1 country.
Jesse MezDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA; Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA. Electronic address: jessemez@bu.edu.
Jaeyoon ChungDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Gyungah JunDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA.
Joshua KriegelDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA; Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA.
Alexandra P BourlasDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA; Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA.
Richard ShervaDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Mark W LogueDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Lisa L BarnesDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
David A BennettDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Joseph D BuxbaumDepartments of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA.
Goldie S ByrdDepartment of Biology, North Carolina A & T State University, Greensboro, NC, USA.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, WA, USA.
Nilüfer Ertekin-TanerDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Denis EvansDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
M Daniele FallinDepartment of Mental Health, Johns Hopkins School of Public Health, Baltimore, MD, USA; Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Alison GoateDepartments of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA.
Neill R Graff-RadfordDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Kathleen S HallDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
M Ilyas KambohDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Walter A KukullDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Eric B LarsonGroup Health, Group Health Research Institute, Seattle, WA, USA.
Jennifer J ManlyDepartment of Neurology and the Taub Institute, Columbia University, New York, NY, USA.
Alzheimer's Disease Genetics Consortium
Jonathan L HainesDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
Richard MayeuxDepartment of Neurology and the Taub Institute, Columbia University, New York, NY, USA.
Margaret A Pericak-VanceThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Gerard D SchellenbergDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kathryn L LunettaDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Lindsay A FarrerDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA; Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Boston University · USRush University Medical Center · USColumbia University · USIcahn School of Medicine at Mount Sinai · USUniversity of Washington · USAlzheimer’s Disease Neuroimaging Initiative · USBloomberg (United States) · USCase Western Reserve University · USGroup Health Cooperative · USIndiana University – Purdue University Indianapolis · USIndiana University School of MedicineMayo Clinic in Florida · USNorth Carolina Agricultural and Technical State University · USUniversity of Miami · USUniversity of Pennsylvania · USUniversity of Pittsburgh · USWinnMed · US
Funding
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MNATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5MAlzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4MWASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MTREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 1985 to 2019
$43.0MTHE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITEU24AG041689 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LI-SAN WANG · 2012 to 2026
$42.3MFurthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3MVESICULAR LOCALIZATION AND FUNCTION OF PRESENILIN 1 FRAGMENTP50AG005138 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHIMMING, CORBETT · 1985 to 2019
$37.9MNHGRI NIH HHS U01 HG008657NIA NIH HHS K23 AG046377NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG013846NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG009029NIA NIH HHS R01 AG009956NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG019085NIA NIH HHS R01 AG020688NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG025259NIA NIH HHS R01 AG026390NIA NIH HHS R01 AG027944NIA NIH HHS R01 AG028786NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG030653NIA NIH HHS R01 AG032990NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG041718NIA NIH HHS R01 AG048927NIA NIH HHS R37 AG015473NIA NIH HHS RC2 AG036528NIA NIH HHS RC2 AG036650NIA NIH HHS RF1 AG015819NIA NIH HHS RF1 AG051504NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG032984NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG026395NIA NIH HHS U24 AG041689NIMHD NIH HHS P20 MD000546NINDS NIH HHS R01 NS080820
Abstract
introductionAfrican Americans' (AAs) late-onset Alzheimer's disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power.
methodsWe conducted a genome-wide association study (GWAS) in AAs employing informed conditioning in 1825 LOAD cases and 3784 cognitively normal controls. We derived a posterior liability conditioned on age, sex, diabetes status, current smoking status, educational attainment, and affection status, with parameters informed by external prevalence information. We assessed association between the posterior liability and a genome-wide set of single-nucleotide polymorphisms (SNPs), controlling for APOE and ABCA7, identified previously in a LOAD GWAS of AAs.
resultsTwo SNPs at novel loci, rs112404845 (P = 3.8 × 10 DISCUSSION: An informed conditioning approach can detect LOAD genetic associations in AAs not identified by traditional GWAS.
Indexed as
Genetic LociPolymorphism, Single NucleotideAgedAged, 80 and overAlzheimer DiseaseApolipoproteins EATP-Binding Cassette TransportersBlack or African AmericanDiabetes ComplicationsEducational StatusFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMicrofilament ProteinsABCA7 protein, humanApolipoproteins EATP-Binding Cassette TransportersCobl protein, humanMicrofilament ProteinsOrganic Anion Transporters, Sodium-Dependentsodium-bile acid cotransporterSymportersABCA7African AmericansAgeAlzheimer's diseaseAPOECOBLDiabetesEducationGenome-wide association study (GWAS)Informed conditioning on clinical covariatesResveratrolSex differencesSLC10A2Smoking
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