Evidence map›Paper›PMID 27770542›Full record

SynthesisBritish journal of clinical pharmacology2017

Sertraline use in the first trimester and risk of congenital anomalies: a systemic review and meta-analysis of cohort studies.

Zi-Qi Shen, Shan-Yan Gao, Shawn Xiang Li, Tie-Ning Zhang, Cai-Xia Liu, Hai-Chen Lv, Yuan Zhang, Ting-Ting Gong, Xin Xu, Chao Ji and 2 more

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 12 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 12 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Zi-Qi ShenDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Shan-Yan GaoDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Shawn Xiang LiInternational Education College, China Medical University, Shenyang, China.
Tie-Ning ZhangDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Cai-Xia LiuDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Hai-Chen LvDepartment of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Yuan ZhangDepartment of Emergency, Shengjing Hospital of China Medical University, Shenyang, China.
Ting-Ting GongDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Xin XuDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Chao JiDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Qi-Jun WuDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Da LiDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
China Medical University · CNDalian Medical University · CNShenyang Medical College · CN

Funding

Vanderbilt-Shanghai Chronic Disease Research Training ProgramD43TW008313 · FIC · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 2009 to 2013
$1.1M
FIC NIH HHS D43 TW008313
6 · The paper itself

Abstract

aimTo perform a meta-analysis of available cohort studies on the association between sertraline use by pregnant women in the first trimester and the findings of congenital anomalies in infants.

methodsA comprehensive search of articles published from the index date up to 31

resultsTwelve cohort studies that involved 6 468 241 pregnant women were identified. We summarized odds ratios (ORs) and 95% confidence intervals (CIs) of congenital anomalies using the random-effects model. Pregnant women who used sertraline in the first trimester had a statistically significant increased risk of infant cardiovascular-related malformations (OR = 1.36; 95% CI = 1.06-1.74; I

conclusionThis meta-analysis suggested that the use of sertraline use by pregnant women in the first trimester had an increased risk of cardiovascular-related malformations as well as atrial and/or ventricular septal defects in infants. Meanwhile, nonsignificant associations between sertraline use and other congenital anomalies were found. More cohort studies are warranted to provide detailed results of other congenital anomalies.

Indexed as

Abnormalities, Drug-InducedCohort StudiesFemaleHumansInfantPregnancyPregnancy Trimester, FirstRiskSelective Serotonin Reuptake InhibitorsSertralineSelective Serotonin Reuptake InhibitorsSertralineantidepressive agentscohort studiescongenital anomaliesmeta-analysispregnancysertraline

Identifiers

PMID27770542
PMCPMC5346877
OpenAlexW2533286547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.