ArticleThe journal of headache and pain2016
Prevalence of restless legs syndrome in migraine patients with and without aura: a cross-sectional, case-controlled study.
Article in The journal of headache and pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Migraine and Restless Legs Syndrome: A Meta-Analysis.Journal of sleep research · 2026Pooled it
- Comorbidities of primary headache disorders: a literature review with meta-analysis.The journal of headache and pain · 2021Pooled it
- Migraine and sleep disorders: a systematic review.The journal of headache and pain · 2020Pooled it
- Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Pooled it
- Insomnia severity in migraine: The role of headache frequency, aura status, and comorbidities-A cross-sectional study.Headache · 2026Article
- The clinical implications of the comorbidity between restless legs syndrome and migraines.Sleep and biological rhythms · 2025Article
- The association between migraine and Parkinson's disease: a nationwide cohort study.Epidemiology and health · 2024Article
- Pathophysiology of Chronic Migraine: Insights from Recent Neuroimaging Research.Current pain and headache reports · 2022Review
- Current Perspectives on the Impact of Chronic Migraine on Sleep Quality: A Literature Review.Nature and science of sleep · 2022Review
- Pathophysiological Bases of Comorbidity in Migraine.Frontiers in human neuroscience · 2021Review
- Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D.Frontiers in neurology · 2021Article
- Association of genetic variants in migraineurs with and without restless legs syndrome.Annals of clinical and translational neurology · 2020Article
- Prevalence of migraine and non-migraine headache and its relation with other diseases in the adults of Aseer Region, Saudi Arabia.Journal of family medicine and primary care · 2020Article
- The Comorbidity of Migraine and Restless Legs Syndrome.Current neurology and neuroscience reports · 2019Review
- Episodic Migraine Comorbidities: Avoiding Pitfalls and Taking Therapeutic Opportunities.Current pain and headache reports · 2019Review
- Patterns of gray matter alterations in migraine and restless legs syndrome.Annals of clinical and translational neurology · 2019Article
- Altered Brain Functional Connectome in Migraine with and without Restless Legs Syndrome: A Resting-State Functional MRI Study.Frontiers in neurology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the comorbidity of migraine and restless legs syndrome (RLS) has been well-documented, the association between RLS and migraine frequency has yet to be elucidated. The present study aims to evaluate the prevalence of RLS among individuals who experience low-frequency, high-frequency, or chronic migraine presenting with and without aura.
methodsWe conducted a cross-sectional, case-controlled study involving 505 participants receiving outpatient headache treatment. Standardized questionnaires were administered to collect information on experiences of migraine, RLS, sleep quality, anxiety, depression, and demographics. Participants were categorized into low-frequency (1-8/month), high-frequency (9-14/month), and chronic (≥15/month) headache groups. RLS was diagnosed according to the criteria outlined by the International RLS Study Group (IRLSSG). The Pittsburgh Sleep Quality Index (PSQI) and Hospital Anxiety and Depression Scale (HADS) were used to assess sleep quality and identify symptoms of anxiety and depression. Associations between migraine frequency and RLS prevalence were investigated using multivariate linear and logistic regression.
resultsUnivariate analysis revealed an effect of migraine frequency on RLS prevalence (p = 0.026), though this effect did not persist following adjustment for baseline characteristics (p = 0.256). The trend was robust in patients whose migraines presented with auras (p
conclusionsHigher migraine frequency correlates with a higher prevalence of RLS, particularly among patients with auras.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.