Evidence map›Paper›PMID 27770278›Full record

ArticleJournal of neuro-oncology2017

Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.

Duthika M Mallawaaratchy, Susannah Hallal, Ben Russell, Linda Ly, Saeideh Ebrahimkhani, Heng Wei, Richard I Christopherson, Michael E Buckland, Kimberley L Kaufman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.

  1. Pooled it
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  9. Current Understanding of the Exosomes and Their Associated Biomolecules in the Glioblastoma Biology, Clinical Treatment, and Diagnosis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Review
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Duthika M MallawaaratchyFaculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, 2006, Australia.
Susannah HallalDiscipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.
Ben RussellDiscipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.
Linda LyBrain and Mind Centre, The University of Sydney, Camperdown, NSW, 2050, Australia.
Saeideh EbrahimkhaniDiscipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.
Heng WeiBrain and Mind Centre, The University of Sydney, Camperdown, NSW, 2050, Australia.
Richard I ChristophersonFaculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, 2006, Australia.
Michael E BucklandDiscipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.
Kimberley L KaufmanFaculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, 2006, Australia. kim.kaufman@sydney.edu.au.ORCID 0000-0002-7239-039X
The University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) play key roles in glioblastoma (GBM) biology and represent novel sources of biomarkers that are detectable in the peripheral circulation. Despite this notionally non-invasive approach to assess GBM tumours in situ, a comprehensive GBM EV protein signature has not been described. Here, EVs secreted by six GBM cell lines were isolated and analysed by quantitative high-resolution mass spectrometry. Overall, 844 proteins were identified in the GBM EV proteome, of which 145 proteins were common to EVs secreted by all cell lines examined; included in the curated EV compendium (Vesiclepedia_559; http://microvesicles.org ). Levels of 14 EV proteins significantly correlated with cell invasion (invadopodia production; r

Indexed as

Biomarkers, TumorBrain NeoplasmsCell Line, TumorExtracellular VesiclesGlioblastomaHumansNeoplasm InvasivenessProteomeProteomicsBiomarkers, TumorProteomeAnnexin a1ExosomeExtracellular vesicleGlioblastomaInvadopodiaProteomics

Identifiers

PMID27770278
PMCPMC5306193
OpenAlexW2538652467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.